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Depression and other nonmotor manifestations such as sleep disturbances are common and disabling features of Parkinson disease (PD).1 These symptoms contribute to poor quality of life and impaired cognitive performance and lead to increased morbidity and mortality in the PD population. Current nonpharmacologic treatment options for depression and other nonmotor symptoms of PD are limited. Pharmacotherapy may be associated with undesirable adverse effects. There is therefore a great need to develop novel treatment modalities.
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