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An estimated two-thirds of boys with adrenoleukodystrophy (ALD) will develop cerebral ALD lesions during their lifetime, with the most concentrated period occurring in the first decade (figure).1,2 Although the pathogenic triggers and risk factors responsible for the genesis of these inflammatory demyelinating lesions remain poorly characterized, the lesions themselves are fairly stereotyped in their anatomical origins, histologic features, and general trajectory.
Footnotes
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