This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Although the risk of stroke increases with age, one-third of stroke hospitalizations in the United States occur in those <65 years of age.1 Recent years have seen a disproportionate increase in stroke in young adults. Between 2000 and 2010, hospitalizations for acute ischemic stroke (AIS) per 100,000 population decreased for those 65 to 84 years of age (from 846 to 605) and those ≥85 years of age (from 2,077 to 1,618) but increased for those 25 to 44 years of age (from 16 to 23) and those 45 to 64 years of age (from 149 to 156).2 Although the causes remain uncertain, other areas around the world demonstrate this same trend.3 Moreover, mortality rates for ischemic stroke for those <45 years of age in the United States increased by 11% to 36% between 1989 and 2009 compared to a 53% decline among older adults.4 Globally, between 1990 and 2013, those 20 to 64 years of age had a 37% increase in disability-adjusted life-years lost due to ischemic stroke.5 Optimization of stroke prevention, acute treatment, and rehabilitation of young adults who have had a stroke is critical for addressing these epidemiologic trends. Although proven to improve outcomes in adult patients with ischemic stroke, scant data exist on the quality of pharmacologic thrombolysis (i.e., IV tissue plasminogen activator [tPA]) for younger patients with AIS.6
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
See page 1138
- © 2019 American Academy of Neurology
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
