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Abstract
Objective To find early hemodynamic predictors of outcome and reperfusion injury in patients with acute ischemic stroke due to anterior circulation large artery occlusion (LAO) after endovascular treatment (EVT).
Methods Serial transcranial color-coded sonography examinations assessed the vessel status and cerebral hemodynamics of 185 (109 [58.9%] men, mean age 69.5 ± 12.3 years) consecutive patients with acute anterior circulation LAO soon after, at 48 hours after, and 1 week after EVT.
Results Successful recanalization (odds ratio [OR] 0.25, 95% confidence interval [CI] 0.11–0.61) and normal peak systolic velocity (PSV) ratio (PSV of recanalized middle cerebral artery/PSV of contralateral middle cerebral artery) at 48 hours (OR 0.22, 95% CI 0.15–0.64) and after 1 week (OR 0.11, 95% CI 0.07–0.31) from EVT were independent predictors of good outcome at 3 months. Thrombectomy failure (OR 10.22, 95% CI 1.47–45.53) and pathologic PSV ratio at 1 week from EVT (OR 15.23, 95% CI 4.54–46.72) were associated with a worse 90-day outcome. Patients who subsequently developed postinterventional intracranial hemorrhage (ICH) showed a higher mean PSV ratio (3.5 ± 0.2 vs 2.4 ± 0.1, p < 0.0001) soon after successful recanalization. In multivariate analysis, early PSV ratio was independently associated with postprocedural ICH (OR 8.474, 95% CI 3.066–45.122, p < 0.01]. At 1 week from EVT, 15 of 21 (71.4%) patients with ICH who resumed normal PSV values had a better 90-day outcome (modified Rankin Scale score 0–2: 40% vs 0%).
Conclusion Post-EVT ultrasound monitoring of stroke patients might be an effective bedside method for assessing treatment efficacy, shedding light on outcome variability and identifying patients at increased risk of ICH.
Glossary
- BFV=
- blood flow velocity;
- CI=
- confidence interval;
- CTA=
- CT angiography;
- CTTS=
- transcranial color-coded sonography;
- DSA=
- digital subtraction angiography;
- EDV=
- end-diastolic velocity;
- EVT=
- endovascular treatment;
- ICA=
- internal carotid artery;
- ICH=
- intracranial hemorrhage;
- IVT=
- IV thrombolysis;
- LAO=
- large artery occlusion;
- MCA=
- middle cerebral artery;
- mRS=
- modified Rankin Scale;
- mTICI=
- modified Treatment in Cerebral Ischaemia;
- NIHSS=
- NIH Stroke Scale;
- OR=
- odds ratio;
- PSV=
- peak systolic velocity;
- TCCS=
- transcranial color-coded sonography;
- TCD=
- transcranial Doppler
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Editorial, page 1127
- Received August 21, 2018.
- Accepted in final form February 6, 2019.
- © 2019 American Academy of Neurology
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