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Stereotactic radiosurgery (SRS) for cavernous malformations (CM) of the brain evolved as a potential treatment to reduce hemorrhage risk after the success of SRS for arterial venous malformations (AVM). A multitude of single-center, treatment-only series of SRS for CM have suggested that SRS may reduce the risk of hemorrhage, but only after an interval of 2–3 years. However, many natural history studies including several large meta-analyses have demonstrated a similar, clustering phenomenon, in the absence of treatment.1 That is, the risk of hemorrhage after first hemorrhage is …
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