文摘
摘要目的:我们评估量化易感性映射(QSM)核磁共振技术来测量大脑铁积累在帕金森病(PD)患者与健康对照组相比,不同阶段。
背景:脑铁沉积在PD的发病机制有关。QSM出现大脑铁作为一种非侵入性技术来量化。然而,相关的大脑积累在黑质和其他铁原子核不完善的疾病的不同阶段。
设计/方法:我们进行了横断面分析78例特发性帕金森病的MRI扫描(n = 16 Hoehn Yahr我(浩英)阶段,n = 39 II期,n = 23阶段iii iv)和31名健康对照组。我们分析了黑质(SN)、红核(RN)、尾状核、壳核和苍白球QSM-processed图像获得磁化率值。
结果:我们发现较高的铁积累SN的PD患者在所有阶段和控制(175.12±45.15磅的阶段我和180.89±44.77十亿分之189.76±58.66磅的II期和iii iv阶段和115.93±29.47磅的控制;P < 0.001),没有统计上的显著差异在PD阶段。铁在RN在统计学上显著增加只有在II期和控件(十亿分之132.68±37.14和105.80±27.48磅;P = 0.0087)。尾状的铁含量,壳核和苍白球任何PD组没有差异和控制。
结论:QSM可以测量铁基底神经节的PD患者。我们的数据显示脑铁沉积发生在发病的早期,只有在SN和RN这些病人。Neuromelanin,自然的铁螯合剂SN,占增加铁的缺乏先进的PD阶段。这是一个大的横断面研究的脑铁沉积在PD浩英登台。前瞻性研究的进一步验证QSM作为一种方法来测量大脑铁,它可以作为疾病生物标志物。
披露:李女士没有披露。约书亚Avecillas没有披露。Thanh阮没有披露。凯利Gillen没有披露。Alexey Dimov没有披露。张爱玲没有披露。布莱恩Kopell已收到个人薪酬在500 - 4999美元的范围为美敦力公司担任顾问。布莱恩Kopell已收到个人薪酬在10000 - 49999美元的范围作为顾问艾伯特神经调节。布莱恩Kopell已收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会Enspire DBS。王教授已经收到知识产权利益从发现或技术有关卫生保健。 Dr. Shtilbans has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Acorda. Dr. Shtilbans has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Amneal. Dr. Shtilbans has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Kyowa Kirin. Dr. Shtilbans has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Neurocrine. Dr. Shtilbans has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for teva. Dr. Shtilbans has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for UCB. Dr. Shtilbans has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for US worldmeds.
