文摘
摘要目的:报告第一批广告患者研究一个新的M4毒蕈碱的胆碱能受体PET示踪剂,(11C] mk - 6884。
背景:胆碱能神经元损失是广告的一个特点。最大的广告目标类的药物乙酰胆碱酯酶为了增加乙酰胆碱的可用性。评估区域胆碱能的语气在个别病人和测量目标接触潜在的治疗方法,是很有帮助的形象毒蕈碱的受体在活的有机体内。几种成像示踪剂开发图像胆碱能受体,但发现这些代理也在消极的或微妙的使用的。最近,一位M4毒蕈碱的胆碱能受体PET示踪了,(11C] mk - 6884,显示良好的成像特点。
设计/方法:九个阿尔茨海默氏症患者(MMSE = 15.2±5.2,平均年龄= 68.9±5.5年,五位女性),接受(11和[C] mk - 6884 M4受体18F] FDG代谢的宠物。M4图像期间获得90分钟后丸注入370兆贝可(11C] mk - 6884。标准摄入值比率(SUVRs)计算使用小脑灰质作为参考。(18F] FDG SUVRs计算标准程序后,使用小脑灰质作为参考。
结果:正如所料,(11高吸收C] mk - 6884显示在基底神经节,在丘脑和较低的值。皮质吸收减少主要在parieto-temporal协会皮层,相应的临床综合征:患者主要语言问题有更大损失在左半球和那些视觉空间的技能障碍的情况则正好相反。额叶也受到了影响,但不如后结构。有一个和谐皮质(11C] mk - 6884和18F] FDG PET值,表明(11C] mk - 6884绑定特定的疾病,但也不和谐的地区,突出的潜在的特异性11C] mk - 6884。
结论:最初的经验(11C] mk - 6884表明这示踪剂可能被证明是有用的在广告形象毒蕈碱的受体。
披露:Belen帕斯卡的机构收到NIH的研究支持。Belen帕斯卡的机构收到NIH的研究支持。保罗到Fregonara没有披露。Meixiang没有披露。昆汀恐慌没有披露。维多利亚Arbones没有披露。Yuchuan王没有披露。文平李没有披露。Amy Cheng获得股票或默克公司的所有者权益。露西安Costa-Frossard已收到个人薪酬在500 - 4999美元的范围作为顾问Almirall,拜耳,生原体,Celgene公司,默克公司Teva,罗氏公司,赛诺菲。 Lucienne Costa-Frossard has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for bayer, biogen, almirall, teva, merck, sanofi, roche, biopas. The institution of Lucienne Costa-Frossard has received research support from biogen, merck, sanofi, roche, almirall. Eric Hostetler has received personal compensation for serving as an employee of Merck & Co., Inc.. Eric Hostetler has received stock or an ownership interest from Merck & Co., Inc. Dr. Basile has received personal compensation for serving as an employee of Merck Research Labs. Dr. Basile has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Above and Beyond Research. Dr. Basile has received stock or an ownership interest from Merck Research Labs. Dr. Basile has received intellectual property interests from a discovery or technology relating to health care. Dr. Masdeu has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Masdeu has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for NCAA. Dr. Masdeu has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Blank and Rome. The institution of Dr. Masdeu has received research support from NIH. The institution of Dr. Masdeu has received research support from Moody Foundation. The institution of Dr. Masdeu has received research support from Abbvie. The institution of Dr. Masdeu has received research support from Biogen. The institution of Dr. Masdeu has received research support from Eli Lilly. The institution of Dr. Masdeu has received research support from Eisai. Dr. Masdeu has received publishing royalties from a publication relating to health care.
