文摘
摘要目的:确定主成分的认知评估电池最佳捕捉mTBI病人的临床状态在多个时间点,可以用来通知选择未来mTBI措施的研究结果。
背景:当前困难mTBI临床试验的设计是认知领域的重叠广泛评估,使用不同的评估来评估一个域,和大的变化评估。需要统计数据简化驱动的策略来确定最准确的域捕获mTBI病人的临床状态。
设计/方法:325名病人和152个对照组mTBI后入学。患者进入遇到1(<具有抑制受损)或延伸72小时遇到2(5 - 10天),并返回遇到3(12到16天)和遇到4(83 - 97天)。在每个遇到,受试者接受了神经心理学评估电池(RPQ, BSI、TMT HVLT,极冰原/有关)。协方差矩阵是计算从临床评估。PCA被用作数据简化策略,阐明的核心维度mTBI后遗症。
结果:在mTBI患者中,有一个高度的症状库存之间的协方差。在神经认知评估,TMT相关显著与极冰原/威和一个较小的程度上从HVLT全面回忆。PCA的主要组件相关主要与TMT-B(0.6),延迟回忆和保留(0.5),和BSI(0.4),并解释了89.7%的方差的数据访问。其余组件解释方差的10.3%。
结论:mTBI人口的患者中,89.7%的方差解释为保持一致的所有遇到的主要组件。临床和神经认知指标重要程度的相关性显示表明神经认知电池可以简化。研究结果有助于未来的临床试验设计同样分层mTBI科目。
披露:谢蒂已收到个人补偿的范围0 - 499美元为在科学咨询服务或数据安全监测委员会Biohaven Pharmaeucticals。谢蒂已收到个人薪酬在500 - 4999美元的范围作为一个mTBI专家证人,Inc .谢蒂的机构已经接到标记AG)研究支持。库马拉斯Madhavan已收到个人赔偿作为通用电气的员工。苏雷什乔尔已经收到个人赔偿作为通用电气的员工。苏雷什乔尔已经收到知识产权利益从发现或技术相关的卫生保健。凯特琳米勒没有披露。马修·加维没有披露。以斯帖金没有披露。约瑟夫T阮没有披露。Masdeu博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会生原体。 Dr. Masdeu has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for NCAA. Dr. Masdeu has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Blank and Rome. The institution of Dr. Masdeu has received research support from NIH. The institution of Dr. Masdeu has received research support from Moody Foundation. The institution of Dr. Masdeu has received research support from Abbvie. The institution of Dr. Masdeu has received research support from Biogen. The institution of Dr. Masdeu has received research support from Eli Lilly. The institution of Dr. Masdeu has received research support from Eisai. Dr. Masdeu has received publishing royalties from a publication relating to health care. Luca Marinelli has received personal compensation for serving as an employee of General Electric.
