文摘
摘要目的:评估区域脑容量差异在影像上孤立综合症患者使用MRI (pwRIS)和健康对照组(高碳钢)
背景:RIS时检测到无症状脑白质病变MRI上和现在的一个机会了解底层女士出现最早的生物过程。现有的研究已经证明,整个大脑pwRIS与高碳钢子结构的数量更少了,但萎缩的时间序列,具体受影响地区优先不完全理解。
设计/方法:3 t脑部核磁共振成像获得的一部分CanProCo研究14 pwRIS(平均年龄:50年,50%女性)和14高碳钢(平均年龄:40年,86%女性)和加工使用分布形态测量学(VBM)管道。在每个RIS主题,灰质(GM)组织类提取从t1加权磁共振成像和co-registered平均创造一个公正的模板。每个主题注册模板和纠正的体积变化由于这种扭曲。区域体积之间的差异进行评估RIS和高碳钢。MACruise大脑分割管道是用来计算脑实质分数(带通滤波器),衡量整个大脑萎缩。
结果:地区小脑半球通用在RIS vs高碳钢小(p < 0.05)。这些地区主要集中在外侧边缘的小脑半球,同时保留小脑蚓体。带通滤波器是小(p < 0.004),唯一的其他大脑区域展示显著减少pwRIS与高碳钢右额叶内侧皮质(p < 0.05)。
结论:小脑半球VBM分析表明地区通用优先萎缩在pwRIS与高碳钢。这些发现表明,小脑可能RIS初始影响的地区之一,可以观察到整个大脑萎缩RIS的主要因素。纵向随访队列的信息来理解大脑子结构的演化影响pwRIS出现症状与女士一致,提供洞察早期生物女士的病理生理学过程。
披露:格莱斯特博士没有披露。梅勒妮Guenette没有披露。Adelia女士没有披露。彭定康博士已经收到个人薪酬在10000 - 49999美元的范围作为一个编辑,副主编,为加拿大精神病协会或编辑顾问委员会成员。彭定康博士已经收到相关出版物的出版版税卫生保健。制度的屁股博士接到CIHR和MSSC研究支持。Tam已收到博士研究的机构自然科学和工程研究委员会的支持。谭博士的机构已经得到实践的研究支持脊髓研究所。Traboulsee博士已经收到个人薪酬在500 - 4999美元的范围为罗氏公司担任顾问。Traboulsee博士已经收到个人薪酬在500 - 4999美元的范围为赛诺菲Genzyme担任顾问。 Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Dr. Traboulsee has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi Genzyme. The institution of Dr. Traboulsee has received research support from Roche. The institution of Dr. Traboulsee has received research support from Genzyme. Dr. Kolind has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Kolind has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Kolind has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Kolind has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. The institution of Dr. Kolind has received research support from Sanofi Genzyme. The institution of Dr. Kolind has received research support from Roche. The institution of Dr. Kolind has received research support from Biogen. Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Roche. The institution of Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen-Idec. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD-Serono. Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi-Genzyme. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Oh has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen-Idec. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi-Genzyme. The institution of Dr. Oh has received research support from Biogen-Idec. The institution of Dr. Oh has received research support from EMD-Serono. The institution of Dr. Oh has received research support from Biogen-Idec.
