文摘
摘要目的:确定自身内在的血压(BP)变化的作用作为一个贡献者白质(WM)损害MRI和评估这些变化对步态速度和不平衡的影响性。
背景:BP在脑血管的健康起着重要的作用和WM完整与性具体影响WM病理机制。自身内在BP可变性的角色作为一个贡献者WM障碍尚不清楚,特别是涉及电机控制区域。
设计/方法:我们确定了990名参与者参加的以人群为基础的梅奥诊所研究衰老的至少2 BP前测量基线MRI。罗彻斯特流行病学项目是用来捕捉血管危险因素和不平衡。我们分析了分数各向异性(FA)和平均扩散系数在WM地区与运动控制有关。我们评估的效果和确定区域影响英国石油公司BP变化。使用结构方程模型(SEM),我们评估了BP斜率对皮质脊髓束的影响(CST) FA和下游影响步态速度和不平衡后年龄和性别的影响。
结果:990名参与者,438人(44%)是女性。高血压是女性和男性之间的相似(67%和70%;p= 0.301)。没有差别的收缩压斜率和两性之间的差异(p= 0.411,p= 0.424)。步速和两性之间的不平衡是相似的(p= 0.506;p= 0.453)。在线性模型预测CST FA,唯一WM地区与BP斜率有关,英国石油公司更大的变化斜率(0.0004;p= 0.026)和女性(0.017;p < 0.001)都降低中科FA的重要预测因子。sem表明,老年、女性性和高BP边坡预测低中科FA,和更低的中科FA的几率更低的步态速度和更高的预测不平衡。
结论:自身内在BP斜率和可变性影响皮质脊髓束连接与女性有损害的敏感性。
披露:库恩博士没有披露。安娜·卡斯蒂略没有披露。盖Lesnick已收到个人赔偿作为梅奥诊所的一名雇员。Mielke博士已经收到个人薪酬在500 - 4999美元的范围为脑保护公司担任顾问。Mielke博士已经收到个人薪酬在500 - 4999美元的范围作为顾问生原体。罗伯特。里德已经收到了来自梅奥诊所研究支持的基础。b .格温温德姆的机构收到NIH的研究支持。彼得森博士已经收到个人薪酬在500 - 4999美元的范围为罗氏公司担任顾问,公司. .彼得森博士已经收到个人薪酬在5000 - 9999美元的范围作为顾问生原体,Inc . .彼得森博士已经收到个人薪酬在5000 - 9999美元的范围作为顾问,卫材公司. . Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck, Inc.. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech, Inc.. Dr. Petersen has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche, Inc.. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Academy of Neurology. The institution of Dr. Graff-Radford has received research support from NIH. Dr. Vemuri has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Miller Medical Communications Inc.. The institution of Dr. Vemuri has received research support from NIH.
