多通道成像和感知功能在两个前部和后部的主要进步面孔失认症患者(赛0 - 3.005)

摘要目的:报告神经成像特性和神经心理学的两个主要进步面孔失认症患者不同解剖参与沿着正确的颞叶。

背景:面孔失认症和右颞病变是常见的,往往在梭状回由血管病变引起的。引起的额颞叶痴呆时,病变通常开始于颞小费。我们对比了神经心理学研究和多通道成像在两个病人的右颞额颞叶痴呆的变体(RTVFTD),一个开始时间提示,另一个在梭状回的后程度。

设计/方法:两个RTVFTD amyloid-negative病人接受了核磁共振和宠物使用¹¹C-PBR28、示踪炎症¹⁸F-flortaucipir。V_T值¹¹C-PBR28计算Logan情节和metabolite-corrected动脉输入函数。为¹⁸F-flortaucipir,小脑灰质的SUV比率计算t = 80 - 100分钟。患者详细的神经心理学评估,包括一个广泛的面部和对象识别电池。

结果:萎缩,¹¹C-PBR28吸收和¹⁸F-flortaucipir吸收参与类似的地区,但在每个病人不同的本地化,北极和梭状回另一个。患者面孔失认症和困难命名任务。然而,患者前病变显示关联面孔失认症,主要是完整的感知能力,但受损表现命名和关联的任务,而患者后病变显示相反的模式,提示严重的统觉的面孔失认症。

结论:虽然从缺血性面孔失认症和其他病变在正确的后temporo-occipital地区很常见,淀粉样蛋白的主要进步面孔失认症没有被描述主要参与的前颞区。以我们的第二个病人,也可以发生在颞参与和在这种情况下,面孔失认症,感知的性质,可以比时间提示时更严重的影响。

披露:布拉德伯里女士没有披露。羞怯的小姐没有披露。阿普尔顿女士没有披露。昆汀恐慌没有披露。维多利亚Arboneshas nothing to disclose. Dr. Masdeu has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Masdeu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Dr. Masdeu has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for NCAA. Dr. Masdeu has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Blank and Rome. The institution of Dr. Masdeu has received research support from NIH. The institution of Dr. Masdeu has received research support from Moody Foundation. The institution of Dr. Masdeu has received research support from Abbvie. The institution of Dr. Masdeu has received research support from Biogen. The institution of Dr. Masdeu has received research support from Eli Lilly. The institution of Dr. Masdeu has received research support from Eisai. The institution of Dr. Masdeu has received research support from Novartis. Dr. Masdeu has received publishing royalties from a publication relating to health care. Dr. Masdeu has received personal compensation in the range of $100,000-$499,999 for serving as a Director, Nantz Nal Alzheimer Center with HOUSTON METHODIST NEUROLOGICAL INSTITUTE. The institution of Belen Pascual has received research support from NIH. The institution of Belen Pascual has received research support from NIH.