文摘
摘要目的:描述一个oligosymptomatic anti-GABA受体脑炎。
背景:对GABA受体的抗体是与各种各样的严重的神经系统功能,形成癫痫持续状态进步的脑病。百分之六十的病人港肿瘤,主要是胸腺瘤。通常脑MRI显示弥漫性cortico-subcortical hyperintense(天赋)病变。
设计/方法:一个60年的老女人恰加斯病的历史和卵巢囊肿表现为头痛和脉动hemisensory综合症也包括面对过去5天。
结果:脑部MRI显示几幕上的cortico-subcortical病变,波动消失,其中一些,新病灶的出现。一些病变显示轻微的钆增强。脑电图显示轻度刺激性的右额颞区域的变化。脑脊液显示10淋巴细胞/ mm3和一些寡克隆条带模式II。广泛的检查对肿瘤、自身免疫和感染性条件是负面的。免疫组织化学研究血清和CSF对啮齿动物的大脑显示GABA受体抗体的存在。她自发恢复,但针对结果,如果静脉注射免疫球蛋白治疗5天课程。她的进化到目前为止(1年的随访)良性的,没有任何进一步的复发。
结论:GABA受体脑炎可能也更良性的演讲,和应该考虑的MRI结果一致。治疗方法在这种情况下仍具有挑战性。
披露:博士Oyarzun Irazu没有披露。色差先生没有披露。秃鹫博士没有披露。古铁雷斯小姐没有披露。卡巴雷若没有披露博士。阿奎莱拉先生没有披露。加西亚博士桑切斯没有披露。Collia费尔南德斯夫人没有披露。Dalmau博士已经收到个人薪酬在10000 - 49999美元的范围作为一个编辑,副主编,或为美国神经病学学会编辑顾问委员会成员。首页立即家人Dalmau博士已收到个人薪酬在5000 - 9999美元的范围作为一个编辑,副主编,或编辑顾问委员会成员Springer自然。 An immediate family member of Dr. Dalmau has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Lamson Dugan & Murray LLP. The institution of Dr. Dalmau has received research support from Sage Therapeutics. The institution of Dr. Dalmau has received research support from Edmond J.Safra Foundation . The institution of Dr. Dalmau has received research support from La Caixa Foundation. The institution of Dr. Dalmau has received research support from Spanish Ministry of Health (ISCIII). The institution of Dr. Dalmau has received research support from Department of Health, Government of Catalunya. Dr. Dalmau has received intellectual property interests from a discovery or technology relating to health care. An immediate family member of Dr. Dalmau has received intellectual property interests from a discovery or technology relating to health care. Dr. Dalmau has received intellectual property interests from a discovery or technology relating to health care. An immediate family member of Dr. Dalmau has received intellectual property interests from a discovery or technology relating to health care. Dr. Dalmau has received publishing royalties from a publication relating to health care. Dr. Dalmau has received publishing royalties from a publication relating to health care. Dr. Dalmau has received publishing royalties from a publication relating to health care. An immediate family member of Dr. Dalmau has received publishing royalties from a publication relating to health care. Dr. Graus has nothing to disclose. Dr. Garcia Monco Carra has nothing to disclose.
