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We appreciate the interest in our research.1 We investigated the neural correlates of social isolation in the UK Biobank and found that socially isolated individuals had lower gray matter volumes in temporal, frontal, and other (e.g., hippocampal) regions. These brain differences related to social isolation were spatially correlated with the expression of genes involved in mitochondrial dysfunction and oxidative phosphorylation. We agree with Dr. Kawada that no casual conclusion should be made in the present study because it is an association study. We avoided using terms that imply causal inferences in the article. In addition, sex may modify the association between social isolation and dementia. Therefore, we have performed a subgroup analysis and found that the association between social isolation and dementia was consistent across sex. In female patients, the fully adjusted HR was 1.24 (95% CI, 1.09–1.40), and in male patients, the fully adjusted HR was 1.26 (95% CI, 1.12–1.42).1
Footnotes
Author disclosures are available upon request (journal{at}neurology.org).
- © 2022 American Academy of Neurology
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