文摘
客观的评估和定性心律失常与LGI1-IgG(富亮氨酸脑胶质瘤灭活1-IgG)自身免疫性脑炎(AE)。
背景AE越来越确定为一个潜在的治疗引起的脑炎。LGI1-IgG是最常见的一种神经特定致病与成人AE相关自身抗体。之前bradyarrhythmias和猝死病例已报告在LGI1-IgG AE,然而,更大的群组研究缺乏。
设计/方法在这个回顾性的描述性研究,我们确定了梅奥诊所的病人(2008年5月1日- 2020年12月31日)与LGI1-IgG AE曾心电图证实bradyarrhythmias在最初的演示。入选标准是1)LGI1-IgG积极性具有一致的临床综合征;2)心电图描记的bradyarrhythmia的证据;和3)足够的临床资料。我们排除了患者bradyarrhythmias交替的原因。我们收集人口/临床资料包括的细节bradyarrhythmia(严重程度、持续时间、治疗),和神经系统和心脏的结果。
结果我们发现患者LGI1-IgG AE bradyarrhythmia 8%的频率在最初的演示。bradyarrhythmia是通常无症状(6/11,55%);然而,这一事件是严重的和一个病人需要起搏器。结果通常也是有利的大多数(8/11,73%)有完整的决议没有进一步的心脏干预。最后,我们发现,老鼠和人类心脏组织表达LGI1(信使rna和蛋白质),这表明LGI1-IgG可能影响心脏组织本身。
结论bradyarrhythmias LGI1-IgG AE可以很少。尽管这种疾病主要是有利的,有些情况下可能需要起搏器安置,以避免灾难性的结果。
脚注
披露:Zhao-Fleming博士没有披露。Zahid博士没有披露。陆医生没有披露。孙太太没有披露。Pittock博士已经收到个人薪酬在5000 - 9999美元的范围作为顾问基因泰克,Inc . Pittock博士已经收到个人薪酬在500 - 4999美元的范围作为顾问圣人疗法,Inc . Pittock博士的机构已收到个人薪酬在500 - 4999美元的范围为阿斯特拉担任顾问。Pittock博士已经收到个人薪酬在500 - 4999美元的范围为主要疗法作为顾问。Pittock博士已经收到个人薪酬在500 - 4999美元的范围作为顾问的联合。Pittock博士已经收到个人薪酬在500 - 4999美元的范围作为顾问罗氏/基因泰克。Pittock博士的机构已收到个人薪酬在500 - 4999美元的范围为Alexion担任顾问。Pittock博士的机构已收到个人薪酬在500 - 4999美元的范围作为顾问/ Viela MedImmune的生物。 Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB, Inc. Dr. Pittock has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Hoffman/LaRoche AG. Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genetech. Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for F. Hofman/LaRoche. The institution of Dr. Pittock has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. The institution of Dr. Pittock has received research support from Grifols. The institution of Dr. Pittock has received research support from NIH. The institution of Dr. Pittock has received research support from Viela Bio/MedImmune/Horizon. The institution of Dr. Pittock has received research support from Alexion Pharmaceuticals. The institution of Dr. Pittock has received research support from F. Hoffman/LaRoche/Genentech. Dr. Pittock has received intellectual property interests from a discovery or technology relating to health care. Dr. Pittock has received intellectual property interests from a discovery or technology relating to health care. Prof. Lee has nothing to disclose. The institution of Dr. Dubey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. The institution of Dr. Dubey has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Astellas. Dr. Dubey has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for AGRIMS. Dr. Dubey has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Advances in Neurology. Dr. Dubey has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Moffit Cancer Center. Dr. Dubey has received research support from Department of Defense. Dr. Dubey has received intellectual property interests from a discovery or technology relating to health care. Dr. Dubey has received intellectual property interests from a discovery or technology relating to health care. Dr. Dubey has received intellectual property interests from a discovery or technology relating to health care.
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