文摘
客观的确定测试n型电压门控钙通道抗体提高血清学诊断性能测试Lambert-Eaton肌无力的综合症。
背景疑似患者自身免疫神经肌肉接点传播疾病通常检测P / Q型(VGCC-P / Q)和n型(VGCC-N)电压门控钙通道抗体援助的诊断Lambert-Eaton肌无力的症状(氨基酸)。
设计/方法这个回顾横断面研究包括93例诊断在梅奥诊所的问题基于电诊法的发现,临床表现和积极的血清学VGCC-P / Q和/或VGCC-N。
结果45例患者(48.4%)是女性,平均年龄61岁(范围11 - 99)。25(26.9%)积极为VGCC抗体类型(参考区间< 0.04 nmol / L (VGCC-N)和< 0.03 nmol / L [VGCC-P / Q]);67例(72.0%)阳性VGCC-P / Q只和一个(1.1%)呈阳性VGCC-N。单只VGCC-N积极结果[VGCC-N = 0.10 nmol / L;VGCC-PQ = 0.02 nmol / L)从一个经典问题表示,没有证据表明恶性肿瘤患者胸部CT。VGCC-N只有积极的患病率低于健康人群或其他疾病控制人口。VGCC-P / Q抗体滴度高的患者可检测共存VGCC-N抗体(平均效价1.58和0.39 nmol / L, P = 0.02)和呈正相关(r = 0.762, P < 0.001)与VGCC-N VGCC-P / Q浓度在双阳性病例。双重积极性并没有显著增加潜在的癌症的可能性(40.9%比30.1%,P = 0.33)。
结论测试VGCC-P / Q在血清学抗体单独是充分评估的氨基酸疑似病例。包含VGCC-N抗体检测不提高诊断性能。积极VGCC-N抗体没有显著增加多种问题的风险。
脚注
披露:马吉德博士没有披露。Zekeridou博士的机构收到罗氏研究支持/基因泰克。Zekeridou博士收到发现或技术知识产权利益有关卫生保健。Zekeridou博士收到发现或技术知识产权利益有关卫生保健。列侬已经收到博士研究的机构国家卫生研究院的支持。列侬博士收到发现或技术知识产权利益有关卫生保健。Pittock博士已经收到个人薪酬在5000 - 9999美元的范围作为顾问基因泰克,Inc . Pittock博士已经收到个人薪酬在500 - 4999美元的范围作为顾问圣人疗法,Inc . Pittock博士的机构已收到个人薪酬在500 - 4999美元的范围为阿斯特拉担任顾问。Pittock博士已经收到个人薪酬在500 - 4999美元的范围为主要疗法作为顾问。Pittock博士已经收到个人薪酬在500 - 4999美元的范围作为顾问的联合。Pittock博士已经收到个人薪酬在500 - 4999美元的范围作为顾问罗氏/基因泰克。 The institution of Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. The institution of Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MedImmune/Viela Bio. Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UCB, Inc. Dr. Pittock has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Hoffman/LaRoche AG. Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genetech. Dr. Pittock has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for F. Hofman/LaRoche. The institution of Dr. Pittock has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion. The institution of Dr. Pittock has received research support from Grifols. The institution of Dr. Pittock has received research support from NIH. The institution of Dr. Pittock has received research support from Viela Bio/MedImmune/Horizon. The institution of Dr. Pittock has received research support from Alexion Pharmaceuticals. The institution of Dr. Pittock has received research support from F. Hoffman/LaRoche/Genentech. Dr. Pittock has received intellectual property interests from a discovery or technology relating to health care. Dr. Pittock has received intellectual property interests from a discovery or technology relating to health care. The institution of Dr. McKeon has received research support from Euroimmun AG. The institution of Dr. McKeon has received research support from National Institutes of Health. Dr. McKeon has received intellectual property interests from a discovery or technology relating to health care. Dr. McKeon has received intellectual property interests from a discovery or technology relating to health care. Dr. McKeon has received publishing royalties from a publication relating to health care. Dr. Klein has a non-compensated relationship as a Klein with Neurology Journal that is relevant to AAN interests or activities. The institution of Dr. Dubey has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UCB. The institution of Dr. Dubey has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Astellas. Dr. Dubey has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for AGRIMS. Dr. Dubey has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Advances in Neurology. Dr. Dubey has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Moffit Cancer Center. Dr. Dubey has received research support from Department of Defense. Dr. Dubey has received intellectual property interests from a discovery or technology relating to health care. Dr. Dubey has received intellectual property interests from a discovery or technology relating to health care. Dr. Dubey has received intellectual property interests from a discovery or technology relating to health care. Dr. Mills has received intellectual property interests from a discovery or technology relating to health care.
- ©2022美国神经病学学会的首页
