文摘
客观的描述功能的中枢神经系统(CNS)脱髓鞘事件后接种冠状病毒疾病19 (COVID-19)。
背景一些报告显示一个潜在的关联COVID-19疫苗和急性中枢神经系统炎症。
设计/方法一系列案例进行女士BARLO中心在多伦多,加拿大安大略省。临床医生报道患者经历急性中枢神经系统脱髓鞘事件后60天内收到至少一个COVID-19疫苗接种从2021年3月到2022年1月。临床特点进行评估。
结果二十个病人标识(中位年龄39年(25 - 82);13(65.0%)的女性)。两人已有的多发性硬化症(MS)。个人获得了辉瑞(n = 14),现代化(n = 5)或阿斯利康(n = 1) COVID-19疫苗。(12)中位数—53天内第一(n = 8)或第二(n = 12)疫苗剂量,患者发展横向脊髓炎(TM) (n = 15),视神经炎(n = 4)或脑脱髓鞘(n = 4)。最后诊断跟踪(平均114天(范围39 - 255))的复发汇款(n = 8)女士post-vaccine TM (n = 5),临床孤立综合征(n = 3),髓少突细胞糖蛋白抗体疾病(n = 2),复发(n = 1)女士和视neuromyelitis谱系障碍(n = 1)。13名患者接受脉冲糖皮质激素,其中,4收到血浆置换。7没有收到急性治疗。回到基线(n = 4) 20.0%, 75.0%部分恢复(n = 15)和5.0% (n = 1)恶化。最后跟进,11在疾病治疗和修改9。9名患者接受后续COVID-19疫苗。其中,一位经验丰富的症状复发没有放射新的脱髓鞘攻击的证据。
结论据我们所知,这是迄今为止最大的系列描述急性中枢神经系统脱髓鞘后接种COVID-19。符合条件的普通人群的疫苗接种是高的情况下,我们无法确定是否脱髓鞘事件的数量高于预期。重复接种疫苗并不是与复发相关的不良事件在这个小观察系列。
脚注
披露:李医生没有披露。Muccilli博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会生原体。Muccilli博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会诺华。Muccilli博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会EMD Serono。施耐德博士已经收到个人薪酬在500 - 4999美元的范围为百时美施贵宝担任顾问。施耐德博士已经收到个人薪酬在500 - 4999美元的范围为诺华公司担任顾问。Selchen博士已经收到个人赔偿范围在10000 - 49999美元的EMD Serono演讲人。Selchen博士已经收到个人薪酬在5000 - 9999美元的范围在罗氏的演讲人。Selchen博士已经收到个人薪酬在5000 - 9999美元的范围在诺华的演讲人。Selchen博士已经收到个人薪酬在10000 - 49999美元的范围为Teva作为专家证人。 Dr. Krysko has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Normative Inc. Dr. Krysko has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Krysko has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Krysko has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Krysko has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Krysko has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. The institution of Dr. Krysko has received research support from Biogen Idec. The institution of Dr. Krysko has received research support from National MS Society.
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