文摘
客观的研究COVID-19疫苗three-dose安全和COVID-19在重症肌无力患者的风险
背景各种疫苗,包括那些反对SARS-CoV-2,据报道引发或加剧重症肌无力(MG)。作为COVID-19可能导致MG患者发展为呼吸衰竭的趋势,研究疫苗的安全性很重要SARS-CoV-2和评估COVID-19 MG患者的风险。
设计/方法在特拉维夫215 MG患者医疗中心,160年采访他们应对三支BNT162b2信使核糖核酸疫苗。我们评估恶化率和安全在6周内从每个疫苗剂量,以及病人的发病率和死亡率在COVID-19与普通人群相比。
结果在150名患者430剂疫苗接种。13例(8.7%)抱怨在6周内恶化(风险)的疫苗剂量,8例(5.3%)经医师报告。风险期间恶化率相似(5.6%)比前一年同期(4.8%)。MG发病比例接种疫苗期间和前几年相比未受影响。15 COVID-19患者恶化率显著提高(40%)相比,利率风险时期接种疫苗后,更高的严重或致命COVID-19(26.7%)比一般人群(0.96%),发生在未接种疫苗,steroid-treated,广义MG患者。
结论Three-dose BNT162b2疫苗既不是与恶化和新的MG发病有关,而COVID-19与未接种疫苗的严重疾病和死亡,steroid-treated广义MG患者。因此,强烈建议对广义MG病人接种
脚注
披露:Doron先生没有披露。Yoav皮乌拉已收到个人补偿的范围0 - 499美元为默克公司担任顾问。Yoav皮乌拉已收到个人补偿的范围0 - 499美元为诺华公司担任顾问。Ifat Vigiser没有披露。哈达尔发现科尔布已收到个人薪酬在500 - 4999美元的范围为诺华公司担任顾问。哈达尔发现科尔布已收到个人薪酬在500 - 4999美元的范围为Marck担任顾问。Regev博士没有披露。史蒂夫Barash已收到Teva的个人作为一个雇员补偿。史蒂夫Barash获得股票或Teva的所有者权益。卡尼博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会Neopharm。 Dr. Karni has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BMS. Dr. Karni has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Israeli Court. The institution of Dr. Karni has received research support from Medison. The institution of Dr. Karni has received research support from Sanofi. The institution of Dr. Karni has received research support from Novartis. The institution of Dr. Karni has received research support from Roche.
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