情景性偏头痛的预防治疗指南考虑Petasites(蜂斗菜)“建立疗效”。[1]的两项研究涉及的蜂斗菜60个病人和100毫克的蜂斗菜。[2]的回顾研究的数据得出结论,“原协议和分析一些主要的缺点。”[3] The second study, in which this author participated, involved 245 patients and showed a daily dose of 100 mg of butterbur extract to be ineffective, while 150 mg was effective.[4] However, the main concern is not efficacy, but safety. The butterbur extract used in these clinical trials has since been reformulated and is no longer available in Germany, where it is manufactured. Unlike the US, Germany regulates herbal products and requires them to undergo teratogenicity and carcinogenicity studies. The original butterbur extract did pass those tests, but the manufacturer did not repeat them for the new formulation. Butterbur contains pyrrolizidine alkaloids, which are hepatotoxic and carcinogenic. In view of the lack of regulation of herbal products in the US and because of the potential for serious toxicity, none of the butterbur extracts, including the one manufactured in Germany, can be safely recommended to our migraine patients.
3所示。Diener, H.C.,Rahlfs, V.W., Danesch, U. The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur. Neurol. 2004;51:89-97.
情景性偏头痛的预防治疗指南考虑Petasites(蜂斗菜)“建立疗效”。[1]的两项研究涉及的蜂斗菜60个病人和100毫克的蜂斗菜。[2]的回顾研究的数据得出结论,“原协议和分析一些主要的缺点。”[3] The second study, in which this author participated, involved 245 patients and showed a daily dose of 100 mg of butterbur extract to be ineffective, while 150 mg was effective.[4] However, the main concern is not efficacy, but safety. The butterbur extract used in these clinical trials has since been reformulated and is no longer available in Germany, where it is manufactured. Unlike the US, Germany regulates herbal products and requires them to undergo teratogenicity and carcinogenicity studies. The original butterbur extract did pass those tests, but the manufacturer did not repeat them for the new formulation. Butterbur contains pyrrolizidine alkaloids, which are hepatotoxic and carcinogenic. In view of the lack of regulation of herbal products in the US and because of the potential for serious toxicity, none of the butterbur extracts, including the one manufactured in Germany, can be safely recommended to our migraine patients.
1。西尔伯斯坦荷兰年代,SD, Freitag F, Dodick DW, Argoff C,清道夫e .循证指南更新:非甾体抗炎药和其他补充章节成人偏头痛的预防治疗。首页Neurology2012; 78:1346 - 1353。
2。格罗斯曼W, Schmidramsl h的提取Petasites hybridus在偏头痛的预防是有效的。交错的地中海2001;牧师6:303 - 310。
3所示。Diener, H.C.,Rahlfs, V.W., Danesch, U. The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur. Neurol. 2004;51:89-97.
4所示。立顿RB, Gobel H, Einhaupl公里,威尔K,莫斯科普。Petasites hybridus根(蜂斗菜)是一种有效的预防性治疗偏头痛。首页神经学2004;63:2240 - 2244。
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