TY - T1的抵押品响应调节time-penumbra关系近端动脉遮挡JF -神经学乔-神经病学SP - e316 LP - e322做- 10.1212 / WNL。首页0000000000004858六世- 90 - 4盟传承Agarwal AU -安德鲁Bivard AU -伊丽莎白·沃伯顿盟-马克·帕森斯盟-克里斯托弗·李维Y1 - 2018/01/23 UR - //www.ez-admanager.com/content/90/4/e316.abstract N2 -客观而临床受益于溶栓首页随时间增加中风发作,急性生理组织间的关系和间接应对中风发病时间尚不清楚。方法我们研究连续患者近端动脉遮挡(n = 355)与全脑灌注CT造影CT发病6小时内的。半影和核心是使用分布定义阈值。组织不匹配被定义为模糊核心的比率。抵押品分数评估使用之前验证视觉评分。结果意味着(SD)是72.1(12.4)岁,中位数(四分位范围)NIH卒中量表评分16(4),平均(SD)成像时间152.5(69.7)分钟。半影卷(枪兵ρ= 0.119,p = 0.026)和不匹配(斯皮尔曼ρ= 0.115,p = 0.030)发生的时间。核心体积减少(斯皮尔曼ρ=−0.112,p = 0.035),抵押品分数随时间增加(斯皮尔曼ρ= 0.117,p = 0.028)。在多变量回归,好抵押品分数预测长时间以来出现(β= 0.101,p = 0.039),而不是预测不匹配(β= 0.001,p = 0.351)。良好的抵押品评分是最强的独立预测指标的最终梗死体积和提高临床赤字。Conclusions In our large patient cohort study of proximal arterial occlusions, we found an incremental collateral response and preserved penumbral volume with time. Thus, tissue viability can be maintained in this time window (0–6 hours) after stroke if leptomeningeal collaterals are able to sustain the penumbra. Our findings suggest that a longer therapeutic window may exist for intra-arterial intervention and that multimodal imaging may have a role in strokes of unknown onset time.AUC=area under the curve; CBF=cerebral blood flow; CBV=cerebral blood volume; CTA=CT angiography; DWI=diffusion-weighted imaging; FLAIR=fluid-attenuated inversion recovery; ICA=internal carotid artery; MCA=middle cerebral artery; MIP=maximum image projection; NCCT=noncontrast CT; NIHSS=NIH Stroke Scale; ROC=receiver operating characteristic ER -