@article {ChuP4.033作者={史黛西楚撒母耳Sommaruga和大卫·黄和珍妮弗·迪尔伯恩和劳伦sans Branden绳和Gargi Samarth尼尔斯·彼得森和艾米丽·吉尔摩约瑟夫·辛德勒和查尔斯Matouk和凯文Sheth和圭多要求},title ={安全结果溶栓对急性缺血性中风患者的颅内出血的历史(P4.033)},体积={90}={15}补充数量,elocation-id = {P4.033} ={2018},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:我们试图确定任何潜在的关联的历史颅内出血患者(我)和死亡率在静脉注射组织纤溶酶原激活物(IV-tPA)对急性缺血性中风(AIS)。首页历史背景:我不再是一个禁忌的IV-tPA AIS。数据安全的结果在这个人口是有限的。设计/方法:使用行政数据录取到加州医院2005年至2011年{\ textendash},我们进行了横断面研究的成年患者承认AIS IV-tPA。ICD-9-CM编码被用来确定病例和确定诊断,包括我亚型和现有的并发症。我们使用多变量逻辑回归模型的概率住院死亡率的函数前我调整了潜在的混杂因素。在因果分析,我们评估死亡率的函数IV-tPA政府与AIS患者承认了我的历史。结果:在372167个招生AIS在研究期间,10882(2.9 \ %)收到IV-tPA(平均年龄70.6(标准差14.6),女性5614 [54.8 \ %])。268(2.5 \ %)我之前的诊断,包括脑出血、蛛网膜下腔出血,硬膜下出血、硬膜外出血。整体死亡率为12.2 \ % 11.7 \ %对病人没有我的历史,和31.0 \ %患者我史(p \ < 2 {\ texttimes} 10 e-16)。独立的调整分析,历史上我仍与死亡率(2.63或3.48,95 \ % CI {\ textendash} 4.56, p \ < 2 {\ texttimes} 10 e-16),正如我亚型:脑出血(2.12或2.97,CI {\ textendash} 4.09, p = 7 {\ texttimes} 10 e-11),蛛网膜下腔出血(1.89或3.15,CI {\ textendash} 5.12, p = 6 {\ texttimes} 10 e-6)。 In patients admitted with AIS with history of ICH, IV-tPA administration was independently associated with mortality (OR 1.77, CI 1.35{\textendash}2.31, P=3{\texttimes}10E-5).Conclusions: In a large sample of patients admitted with AIS who received IV-tPA, history of ICH was independently associated with significantly increased mortality. Future efforts should be directed towards identifying possible subgroups in whom IV-tPA may be safe.Disclosure: Dr. Chu has nothing to disclose. Dr. Sommaruga has nothing to disclose. Dr. Hwang has nothing to disclose. Dr. Dearborn has nothing to disclose. Dr. Sansing has nothing to disclose. Dr. Cord has nothing to disclose. Dr. Samarth has nothing to disclose. Dr. Petersen has nothing to disclose. Dr Gilmore has nothing to disclose. Dr. Schindler has nothing to disclose. Dr. Matouk has nothing to disclose. Dr. Sheth has nothing to disclose. Dr Falcone has nothing to disclose.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/90/15_Supplement/P4.033}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }