RT期刊文章SR电子T1安全结果急性缺血性中风的溶栓患者颅内出血的历史(P4.033)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P4.033 VO 90 15补充A1史黛西楚A1撒母耳Sommaruga A1大卫黄A1詹妮弗·迪尔伯恩A1劳伦sans A1 Brande首页n绳A1 Gargi Samarth A1尼尔斯·彼得森A1艾米莉·吉尔摩A1查尔斯约瑟夫·辛德勒A1 Matouk A1凯文Sheth A1圭多要求年2018 UL //www.ez-admanager.com/content/90/15_Supplement/P4.033.abstract AB目的:我们试图确定任何潜在的关联的历史颅内出血患者(我)和死亡率在静脉注射组织纤溶酶原激活物(IV-tPA)对急性缺血性中风(AIS)。历史背景:我不再是一个禁忌的IV-tPA AIS。数据安全的结果在这个人口是有限的。设计/方法:使用行政数据录取到加州医院2005 - 2011年之间,我们进行了横断面研究的成年患者承认AIS IV-tPA。ICD-9-CM编码被用来确定病例和确定诊断,包括我亚型和现有的并发症。我们使用多变量逻辑回归模型的概率住院死亡率的函数前我调整了潜在的混杂因素。在因果分析,我们评估死亡率的函数IV-tPA政府与AIS患者承认了我的历史。结果:在372167个招生AIS在研究期间,10882(2.9%)接受了IV-tPA(平均年龄70.6(标准差14.6),女性5614 [54.8%])。268例(2.5%)有我之前的诊断,包括脑出血、蛛网膜下腔出血,硬膜下出血、硬膜外出血。总体死亡率12.2%,11.7%的病人没有我的历史,31.0%患者的历史我(p < 2×10 e-16)。调整分析,历史上与死亡率相关的我依然独立(或3.48,95%可信区间2.63 - -4.56,p < 2×10 e-16),我子类型:脑出血(置信区间2.12 - -4.09或2.97,p = 7×10 e-11),蛛网膜下腔出血(置信区间1.89 - -5.12或3.15,p = 6×10 e-6)。 In patients admitted with AIS with history of ICH, IV-tPA administration was independently associated with mortality (OR 1.77, CI 1.35–2.31, P=3×10E-5).Conclusions: In a large sample of patients admitted with AIS who received IV-tPA, history of ICH was independently associated with significantly increased mortality. Future efforts should be directed towards identifying possible subgroups in whom IV-tPA may be safe.Disclosure: Dr. Chu has nothing to disclose. Dr. Sommaruga has nothing to disclose. Dr. Hwang has nothing to disclose. Dr. Dearborn has nothing to disclose. Dr. Sansing has nothing to disclose. Dr. Cord has nothing to disclose. Dr. Samarth has nothing to disclose. Dr. Petersen has nothing to disclose. Dr Gilmore has nothing to disclose. Dr. Schindler has nothing to disclose. Dr. Matouk has nothing to disclose. Dr. Sheth has nothing to disclose. Dr Falcone has nothing to disclose.