@article {DubeyP5.401作者= {Dubey Divyanshu和肖恩Pittock和塞西莉亚凯利和安德鲁·麦肯和a·塞巴斯蒂安Lopez-Chiriboga万带兰列侬和Avi Gadoth Carin史密斯和桑德拉·布莱恩特和克里斯托弗·克莱因和艾伦Aksamit米歇尔•托莱达诺和布拉德利Boeve Jan Mendelt Tillema和Eoin弗拉纳根},title ={自身免疫性脑炎的发病率和患病率和传染性脑炎的比较:以人群为基础的研究(P5.401)},体积={90}={15}补充数量,elocation-id = {P5.401} ={2018},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:我们评估自身免疫性脑炎和发病率和患病率比较自身免疫性和传染性脑炎的流行病学。首页背景:以人群为基础的研究缺乏自身免疫性脑炎发病率和患病率。意识的流行病学是至关重要的资源配置和医疗保健计划。设计/方法:我们进行以人群为基础的发病率和患病率的比较研究自身免疫性和传染性脑炎在奥姆斯特德县,美国。自身免疫性脑炎诊断及其子组被定义为最近出版的诊断标准。年龄计算sex-adjusted患病率和发病率,并使用泊松回归相比。结果:自身免疫性脑炎的流行于2014年1月1日,13.2/100000没有明显不同于所有传染性脑炎(11.6/100000;p = 0.75)或病毒子类别(8.3/100000;p = 0.23)。的发病率(1995 {\ textendash} 2015)自身免疫性和传染性脑炎分别为0.8/100000和1.0/100000组(p = 0.58)。复发或复发住院比传染性高自身免疫性脑炎(p = 0.04)。 The incidence of autoimmune encephalitis increased over time from 0.4/100,000 person-years (1995{\textendash}2005) to 1.2/100,000 person-years (2006{\textendash}2015) (p=0.02), attributable to increased recognition of autoantibody-positive cases. The incidence (2.3 vs 0.7/100,000 person-years; p=0.01) and prevalence (38.3 vs 12.9/100,000; p=0.03) of autoimmune encephalitis was higher among African-Americans than Caucasians. Additionally, males had a significantly higher prevalence of autoimmune encephalitis than females (19.0 vs 7.2/100,000, p=0.04). The prevalence of specific neural autoantibody biomarkers among the definite autoimmune encephalitis category was: glutamic acid decarboxylase-65 (GAD65) (1.9/100,000); unclassified neural autoantibody (1.4/100,000); myelin-oligodendrocyte-glycoprotein (MOG) (1.3/100,000); leucine-rich glioma-inactivated-protein-1 (LGI1) (0.7/100,000); collapsin response-mediator protein-5 (CRMP5) (0.7/100,000); N-methyl-D-aspartate-receptor (NMDAR) (0.6/100,000); anti-neuronal nuclear antibody-2 (ANNA-2/anti-Ri) (0.6/100,000) and glial fibrillary acidic protein-α (GFAPα) (0.6/100,000).Conclusions: This study shows that the prevalence and incidence of autoimmune encephalitis is comparable to infectious encephalitis and its recognition is increasing over time.Disclosure: Dr. Dubey has nothing to disclose. Dr. Pittock has nothing to disclose. Dr. Kelly has nothing to disclose. Dr. McKeon has received research support from Medimmune, Euroimmun, Grifols and Alexion. Dr. Lopez has nothing to disclose. Dr. Lennon has received royalty, license fees, or contractual rights payments from RSR, royalties from sale kits for AQP4 IgG detetction and from clinical service assays performed outside Mayo clinic. Dr. Gadoth has nothing to disclose. Dr. Smith has nothing to disclose. Dr. Bryant has nothing to disclose. Dr. Klein has nothing to disclose. Dr Aksamit has nothing to disclose. Dr. Toledano has nothing to disclose. Dr. Boeve has received research support from GE Heathcare and Axovant. Dr. Tillema has nothing to disclose. Dr Flanagan has nothing to disclose.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/90/15_Supplement/P5.401}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }