Elisabetta Sarasso PT -期刊文章盟盟——Federica Agosta AU -亚历山德拉Tomic盟Nataša DragaševićAU -滨Svetel盟- Elisa Canu AU -弗拉基米尔Kostic AU -马西莫菲利皮主持TI -大脑的结构性变化局部肌张力障碍——任务特异性呢?多通道成像研究(S30.004) DP - 2018年4月10 TA -神经病学PG - S30.004 VI - 9首页0 IP - 15补充4099 - //www.ez-admanager.com/content/90/15_Supplement/S30.004.short 4100 - //www.ez-admanager.com/content/90/15_Supplement/S30.004.full所以Neurology2018 4月10;90 AB -目的:探讨灰色和白质病变患者的特定于任务(TSD)和non-taskspecific肌张力障碍(NTSD)来定义公共和类属特异性的大脑变化。背景:大脑基底神经节异常,丘脑、小脑和感觉运动皮层被认定为共同特征的局灶性肌张力障碍heterogeneus表型表达。然而,task-specificity出现在某些形式的肌张力障碍仍然是一个鲜为人知的现象。不同的病理生理机制可能构成和NTSD TSD中。设计/方法:患者36 TSD(痉挛性发声困难和作家的抽筋),61例NTSD(睑痉挛和颈肌张力障碍),和83名健康对照组包括在这项研究。参与者进行了3 d t1和扩散张量磁共振成像来研究大脑皮层厚度、基底神经节体积,WM呼吸道损伤。结果:与健康对照组相比,TSD患者普遍,双边WM大片损害包括优势和劣势纵向纤维束、扣带包,前丘脑辐射和皮质脊髓束。NTSD病人健康对照组相比有更多的焦点和右横向损伤。顶点皮质厚度的分析显示,正确的pars triangularis NTSD皮质萎缩。Conclusions: TSD is characterised by disruption of the main subcortical motor and cognitive controlling networks suggesting complex pathophysiology of task-specificity of dystonia.Study Supported by: Ministry of Education and Science Republic of Serbia (Grant #175090).Disclosure: Dr. Sarasso has nothing to disclose. Dr. Agosta has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with EXCEMED— Excellence in Medical Education. Dr. Tomic has nothing to disclose. Dr. Dragaþevic has nothing to disclose. Dr. Svetel has nothing to disclose. Dr. Canu has nothing to disclose. Dr. Kostic has received personal compensation in an editorial capacity for Novartis and Boehriner Ingelheim. Dr. Kostic has received research support from Valeant, Stada, Novartis and Boehriner Ingelheim. Dr. Filippi has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biogen Idec, Merk-Serono, Novartis, Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in an editorial capacity for Journal of Neurology. Dr. Filippi has received research support from Biogen Idec, Novartis, Teva Pharmaceutical Industries.