@article {RossorS35.004作者={汤姆Rossor Sukhvir赖特和苏菲Duignan奥尔加Ciccarelli和克里希纳Das伊万杰琳沃斯默和明Lim谢丽尔海明威和雅艾尔Hacohen}, title ={发作在演示儿童疾病复发的预测指标呈现急性播散性脑脊髓炎(S35.004)},体积={90}={15}补充数量,elocation-id = {S35.004} ={2018},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:本研究的目的是确定癫痫发作的频率在两个MOG-Ab正面和负面的急性播散性脑脊髓炎(ADEM)和评估如果癫痫表现的预测复发疾病过程和发布ADEM癫痫。首页背景:虽然最初被认为是一个主要白质病,越来越多的报告的成人和儿童髓少突细胞糖蛋白抗体(MOG-Ab)相关疾病出现灰质病和癫痫发作。设计/方法:孩子出现ADEM是确定从三叔儿科神经病学中心在2005年和2017年之间和案例笔记了。首页MOG-Ab测试作为临床评估的一部分与髓鞘脱失的儿童。结果:72名儿童被识别。MOG-Ab是积极的在48(67 \ %)的情况。28(39 \ %)的那些孩子继续进一步神经复发。复发在MOG-Ab积极的孩子更常见(26/48和2/24;p = 0.001) .15/72(20.8 \ %)儿童在急性发作表现与亚当。有一个趋势更多的癫痫发作MOG-Ab阳性组(13/48和2/24;p = 0.07)。亚当后癫痫的诊断报告在14/73(19.4 \ %),还有一个趋势更持续的癫痫发作最后随访MOG-Ab阳性组(12/48和2/24;p = 0.12)。Seizure at onset were more frequent in the relapsing group than those with monophasic disease (10/28 vs 5/44; p=0.01); and ongoing seizures were more common in the relapsing group (9/28 vs 4/40; p=0.01). The odds ratio of relapsing disease with seizures at onset of first episode of demyelination was 4.3 (95\% CI 1.3{\textendash}14.5; p=0.02).Conclusions: MOG-Ab positivity was associated with a higher rate of relapse flowing ADEM. Seizures at first presentation is predictive of a relapsing disease course. These findings have both diagnostic and treatment implications.Disclosure: Dr. Rossor has nothing to disclose. Dr. Wright has nothing to disclose. Dr. Duignan has nothing to disclose. Dr. Ciccarelli has nothing to disclose. Dr. Das has nothing to disclose. Dr. Wassmer has nothing to disclose. Dr. Lim has nothing to disclose. Dr. Hemingway has nothing to disclose. Dr. Hacohen has nothing to disclose.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/90/15_Supplement/S35.004}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }