TY - T1的癫痫在演示儿童疾病复发的预测指标呈现急性播散性脑脊髓炎(S35.004) JF -神经学乔-神经学六世- 90 - 15补充SP - S35.004盟汤姆Rossor AU -赖特Sukhvir盟苏菲Duignan AU -奥尔加Ciccarelli盟-克里希纳Das AU -伊万杰琳沃斯默AU首页 -明Lim盟谢丽尔海明威盟雅艾尔Hacohen Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/S35.004.abstract N2 -目的:本研究的目的是确定癫痫发作的频率在两个MOG-Ab正面和负面的急性播散性脑脊髓炎(ADEM)和评估如果癫痫表现的预测复发疾病过程和发布ADEM癫痫。背景:虽然最初被认为是一个主要白质病,越来越多的报告的成人和儿童髓少突细胞糖蛋白抗体(MOG-Ab)相关疾病出现灰质病和癫痫发作。设计/方法:孩子出现ADEM是确定从三叔儿科神经病学中心在2005年和2017年之间和案例笔记了。首页MOG-Ab测试作为临床评估的一部分与髓鞘脱失的儿童。结果:72名儿童被识别。MOG-Ab在48(67%)的情况下是积极的。28(39%)的那些孩子继续有一个进一步的神经复发。复发在MOG-Ab积极的孩子更常见(26/48和2/24;p = 0.001) .15/72儿童(20.8%)和亚当在急性发作表现。有一个趋势更多的癫痫发作MOG-Ab阳性组(13/48和2/24;p = 0.07)。亚当后癫痫的诊断报告在14/73(19.4%),还有一个趋势更持续的癫痫发作最后随访MOG-Ab阳性组(12/48和2/24;p = 0.12)。Seizure at onset were more frequent in the relapsing group than those with monophasic disease (10/28 vs 5/44; p=0.01); and ongoing seizures were more common in the relapsing group (9/28 vs 4/40; p=0.01). The odds ratio of relapsing disease with seizures at onset of first episode of demyelination was 4.3 (95% CI 1.3–14.5; p=0.02).Conclusions: MOG-Ab positivity was associated with a higher rate of relapse flowing ADEM. Seizures at first presentation is predictive of a relapsing disease course. These findings have both diagnostic and treatment implications.Disclosure: Dr. Rossor has nothing to disclose. Dr. Wright has nothing to disclose. Dr. Duignan has nothing to disclose. Dr. Ciccarelli has nothing to disclose. Dr. Das has nothing to disclose. Dr. Wassmer has nothing to disclose. Dr. Lim has nothing to disclose. Dr. Hemingway has nothing to disclose. Dr. Hacohen has nothing to disclose. ER -