PT -期刊文章盟温迪凯盟-劳里瓦格纳盟托尔斯坦AU -托马斯·贝尔盟本Buehrer AU -莫林奥尔TI -成功的后期神经组织的集合:全国ALS Biorepository经验(P4.437) DP - 2018年4月10 TA -神经病学PG - P4.437 VI - 90 IP - 15补充4099 - //www.ez-admanager.com/content/90/15_Supplement/P4.437.short 4100 - //www.ez-admanager.com/content/90首页/15_Supplement/P4.437.full所以Neurology2018 4月10;90 AB -目的:这个biorepository的初衷是为了收集和提供为未来的研究与ALS researchersspecimens。背景:Amyotrophiclateral硬化(ALS),通常被称为卢伽雷氏症,aprogressive和致命的神经肌肉疾病。尽管ALS尚无明确的原因,家族性肌萎缩性侧索硬化症(一种遗传性)在5% - -10%的情况下发生。许多假设制定什么引起肌萎缩性侧索硬化症,包括化学风险、职业暴露、兵役体育活动,和创伤。生物标本需要预先研究的原因和治疗肌萎缩性侧索硬化症。国家ALS Biorepository全国ALS组件注册表,收集和银行和尸检标本ALS的人。设计/方法:成功收集后期组织在美国需要一个团队包括协调员,diener,神经病理学家和家人的参与者。后期收藏品包括大脑、脊髓、脑脊髓液,肌肉,骨骼,和皮肤。组织收集是通过国家的疾病研究协调的交换(NDRI)。我们的目标是为集合在24小时内完金宝搏188手机app成的死亡和运到实验室进行处理。Results: Through September 30, 2017, we have obtained consent from 62 participants from 28 states and obtained postmortem donations from 25 participants. The first 20 cases examined showed neuropathological-confirmed ALS with TDP-43 inclusions (ALS-TDP) with a meanage at death of 64 years (range: 52–76), 40% male, and mean brain weight of 1269g. Sixty-five percent of subjects had co-morbid pathological diseases, including the neuropathological changes of Alzheimer disease, primary age-related tauopathy, Lewy body disease, vascular disease with infarcts, encephalitis, and tumor(s).Conclusions: Through a diligent, coordinated effort among partners, we have created a successful postmortem tissue collection system for persons with ALS throughout the United States. These tissues are a valuable resource for research into the causes and treatments for ALS.Study Supported by: The Agency for Toxic Substances and Disease RegistryDisclosure: Dr. Kaye has nothing to disclose. Dr. Wagner has nothing to disclose. Dr. Stein has nothing to disclose. Dr. Bell has nothing to disclose. Dr. Buehrer has nothing to disclose. Dr. Orr has nothing to disclose.

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