RT期刊文章SR电子T1等离子体生物标志物在神经退行性疾病早期阶段(P3.027)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P3.027 VO 90 15 A1范妮同时补首页充A1 Kaitlin Casaletto A1亚当Staffaroni A1约翰·纽豪斯A1 Yann Cobigo A1艾米丽·福克斯A1萨曼莎·沃尔特斯A1玛丽Altendahl A1瑞安惠誉A1安娜Karydas A1杰森何曼A1 Charles DeCarli A1亚当拳击手A1吉尔Rabinovici A1霍华德·罗森A1布鲁斯·米勒A1乔尔·克雷默年2018 UL //www.ez-admanager.com/content/90/15_Supplement/P3.027.abstract AB目的:调查协会的血浆炎症生物标记,gliopathy,与认知功能和神经退行性变的,成像标记神经退化的神经病理和临床阶段。背景:最近的数据表明免疫失调的作用,血脑屏障功能障碍,神经胶质激活早期的神经退行性疾病。通过改进技术、非侵入性的生物标志物的分子病理越来越可行,呈现独特的早期疾病检测和干预的机会,当治疗效果可能最大。设计/方法:参与者包括52个成年人生物标志物阳性阿尔茨海默病(AD) (MMSE ~ 29), 22个成年人与小血管疾病根据MRI法泽卡斯得分> = 2,和65年从纵向观察研究正常认知能力的成人选择在我们的中心。参与者完成了认知测试,神经系统检查,健康调查表,抽血。分析了等离子体使用immuno-based化验炎症标记(TNFa,白细胞介素6、IL1b IP10), gliopathy (GFAP)、神经退化(NFL),和生长激素与神经可塑性和血管生成(脑源性神经营养因子,VEGF)。统计分析包括组差异,回归建模、分类和聚类进行。结果:外周炎症标记物在cSVD最显著升高,紧随其后的是老年认知正常组。在广告GFAP显著升高,与NFL只在广告。虽然标记gliopathy、神经可塑性和神经退化平均低cSVD广告和控制相比,他们显示cSVD最高的与认知功能。等离子体标记的神经可塑性和神经退化是最重要的与脑萎缩在MCI阶段相关的广告。Conclusions: Plasma markers of inflammation, gliopathy, and neurodegeneration show differential association with cognition and imaging markers of neurodegeneration in different disease states and stages, with strongest associations in early disease stage. Their use could improve selection of at risk populations for early implementation of preventive and therapeutic measures.Disclosure: Dr. Elahi has nothing to disclose. Dr. Casaletto has nothing to disclose. Dr. Staffaroni has nothing to disclose. Dr. Neuhaus has nothing to disclose. Dr. Cobigo has nothing to disclose. Dr. Fox has nothing to disclose. Dr. Walters has nothing to disclose. Dr. Altendahl has nothing to disclose. Dr. Fitch has nothing to disclose. Dr. Karydas has nothing to disclose. Dr. Hinman has nothing to disclose. Dr. DeCarli has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Novartis Pharmaceuticals. Dr. Boxer has nothing to disclose. Dr. Rabinovici has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Genentech, Merck. Dr. Rosen has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Kramer has nothing to disclose.