PT -期刊文章盟Nazeem Arsalan AU -莱斯利·莫里森盟Asad Ikram盟-爱征服者AU -海伦金盟-杰弗里·纳尔逊AU -布莱恩·l·哈特TI -在家族性颅内出血脑海绵状畸形:临床表现和MRI偶然发现后续成像(P1.237) DP - 2018年4月10 TA -神经病学PG - P1.237 VI - 90 IP - 15补充4099 - //www.ez-admanager.com/content/90/15_Supplement/P1.237.short 4100 - //www.ez-admanager.com/content/90/15_Supplement/P1.237.full所以Neurology2018 4月1首页0;90 AB -目的:我们的目的是研究新墨西哥州拉美裔人口与脑海绵状畸形类型普通1西班牙突变(CCM1-CHM)理解和描述表型表达和颅内出血(我)在这些患者。背景:脑海绵状畸形(CCM)可以在0.1总人口的-0.5%。大约20 - 50%病例家族,最常见的是CCM-1。有广泛的变异性疾病严重程度甚至家庭成员之一。设计/方法:我们前瞻性的88 CCM1-CHM突变患者从2009 - 2014年基线和纵向随访MRI。成像检查包括存在,数量、位置、大小,CCMs的信号强度特征。记录审查包括病人和家庭历史和基线特征,随访期间,许多病变看到以前和数量,新病灶的位置。我们回顾了基线表示,症状/体征持续时间和是否行手术出血的症状。结果:八十八例患者,12我通过MRI确诊,其中一半是症状。六个患者中度到严重的临床表现包括癫痫、严重头痛(HA)、恶心、呕吐、口齿不清,失语症和面部的弱点,需要手术治疗,一个患者髓术后出血死亡。 The remaining six patients were found to have ICH on follow-up MRI, and one had seizures, headache, nausea, diplopia, and loss of consciousness. MRI played a pivotal role in diagnosing either hemorrhage of previously known lesions, increase in the lesion size and identification of new lesions.Conclusions: Signs and symptoms of ICH in CCM1 patients may result in high morbidity and mortality if ICH occurs. Prompt surgical evaluation is required with frequent intervention.Study Supported by: NINDSDisclosure: Dr. Arsalan has nothing to disclose. Dr. Morrison has nothing to disclose. Dr. Ikram has nothing to disclose. Dr. Zafar has nothing to disclose. Dr. Kim has nothing to disclose. Dr. Nelson has nothing to disclose. Dr. Hart has nothing to disclose.

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