RT期刊文章SR电子T1评估脑代谢活动的Atkins-based饮食用光谱学先生——可行性研究在神经学神经学神经胶质瘤患者(P6.146)摩根富林明乔FD Lippincott Williams &威尔金斯SP P6.146 VO 90 15补充A1 Karisa Schreck A1亚当•伯林顿A1博比Henry-Barron A1林赛·布莱首页尔A1亚当·哈特曼A1埃里克·科索夫A1琳达复活节A1克里斯甲沟炎A1 Fang-Chi许A1 Mackenzie Cervenka A1 Jaishri布莱克利正在A1彼得·巴克A1罗伊Strowd年2018 UL //www.ez-admanager.com/content/90/15_Supplement/P6.146.abstract AB目的:测量光谱差异之前和之后的神经胶质瘤患者的生酮饮食。背景:饮食疗法导致酮体生产正在评估作为潜在的治疗许多神经系统疾病。这个试点研究评估的可行性和活动质子光谱先生(夫人)检测脑代谢活动的8周神经胶质瘤Atkins-based饮食(高兴)。设计/方法:患者II-IV级星形细胞瘤登记完成最初的治疗之后,之前第一次复发。很高兴由20 gm net-carbohydrate限制(修改后的阿特金斯饮食法)以及2天/周热量限制推荐日摄食量的20%。夫人进行病变和侧半球的镜体素在基线和第八周。数据分析使用“LCModel”项目评估酮体(丙酮(Ace), beta-hydroxybutyrate (BHB),乙酰乙酸盐(中航商用飞机有限公司)),2-hydroxyglutarate (2-HG),并设置标准的代谢物对大脑MRS.Results:临时分析报告后14个病人登记:平均年龄50±11年;8男;5年级第四星形细胞瘤。两个病人没有完成这项研究;一个是unevaluable数据排除在外。在基线,tNAA浓度(p < 0.028), Ins (p < 0.01),和Lac (p < 0.023)不同病变和正常的大脑。 Ketone body concentrations were nearly undetectable at baseline; however by week 8, Ace and BHB were reliably detected in lesion([Ace]=0.06–>0.19±0.17, p=0.012; [BHB]=0.06–>0.46±0.59, p=0.05) and contralateral brain([Ace]=0.05–>0.12±0.11, p=0.009; [BHB]=0.12–>0.27±0.23, p=0.007). BHB rose by 0.82 mM from baseline to Week 8 in IDH1 mutant tumors compared to a decrease by −0.13 mM in wild-type gliomas(p<0.002). Increases in BHB were greater in grade III compared to grade IV gliomas(p=0.05), while increases in Ace were associated with greater dietary compliance by urine ketones(p<0.03) and fasting glucose(r=−0.85, p<0.004).Conclusions: Monitoring ketogenic dietary interventions with MRS is feasible. Moreover, tumors harboring IDH mutations and patients with greater dietary compliance appear to have greater cerebral metabolic activity, suggesting a role for MRS in evaluating tumor type and degree of intracerebral metabolic ketosis during treatment.Study Supported by:This study was supported by the Comprehensive Cancer Center of Wake Forest University and the generous philanthropy of our donors.Disclosure: Dr. Schreck has nothing to disclose. Dr. Berrington has nothing to disclose. Dr. Henry-Barron has nothing to disclose. Dr. Blair has nothing to disclose. Dr. Hartman has nothing to disclose. Dr. Kossoff has nothing to disclose. Dr. Easter has nothing to disclose. Dr. Whitlow has nothing to disclose. Dr. Hsu has nothing to disclose. Dr. Cervenka has nothing to disclose. Dr. Blakeley has nothing to disclose. Dr. Barker has nothing to disclose. Dr. Strowd has nothing to disclose.

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