首页TY - JOUR T1 - Seizure Semiologies and Effects of Anti-epileptic Drugs in Patients with Leucine-rich glioma-inactivated-1 ligand antibody (LGI1-Ab) Autoimmune Epilepsy (S11.003) JF - Neurology JO - Neurology VL - 90 IS - 15 Supplement SP - S11.003 AU - Christopher Lamb AU - Jeffrey Britton AU - Sean Pittock AU - Avi Gadoth AU - Andrew McKeon AU - Christopher Klein AU - Anteneh Feyissa Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/S11.003.abstract N2 - Objective: To characterize seizure semiology and utility of anti-epileptic drug (AED) therapy in leucine-rich glioma-inactivated-1 ligand antibody (LGI1-Ab) autoimmune epilepsy (AE).Background: The role of AED therapy in LGI1-Ab AE is underemphasized and unclear.Design/Methods: We identified patients with voltage gated potassium channel complex (VGKCc) titers higher than 0.02 nmol/L who were evaluated May 2008–June 2016 at the three Mayo Clinic sites (Arizona, Florida, or Minnesota).回溯性审查只有LGI1Ab+并提交查获的病人。Results:我们识别到1,095名VGKC乳房高于0.02Nmol/L的病人,其中77名LGI1-Ab呈阳性其中有56名发作病人接受了分析平均显示年龄为62.9岁66%(n=37)为男性最常用的抓取分量为fiobrachial扰动抓取(FBDS)(n=35,63%),紧随其后的焦点认知度(FIA)(n=29,52%),广度异步调(GTCs)(n=28,50%)和焦点知非运动者(n=28,50%)。多数人多取一种型号(n=49 88%!中值=2.5)38名病人(68%)免费发作:29名病人(76%)使用免疫理疗,5名病人(13%)单用AEDs,4名病人(11%)经免疫理疗后使用AEDslevetrastam(n=47,84%)和Valproic酸(n=21,38%)最常用AEDs,但两者均不赋予查封自由权带钠信道阻塞性能非NCBAEDs非9/50vs0/84p=0.00FBDS病人比AEDs更容易响应免疫法(20/30对3/34,p=0.001)。提交非FBDS查获的病人的免疫法和AED响应率没有差别AED响应独立于MRI或EEG异常或认知功能失全CBAED比其他AEDs更有可能授予查封自由Lamb没什么可透露博士布列顿没什么可透露博士Pittock没有什么披露博士加多斯没有什么可透露博士mackon从Medimune、Eurioimune、Grifols和Axion获得研究支持博士Klein没什么可透露博士Feyissa没有什么可透露ER-