RT期刊文章SR电子T1发作符号学和效果的抗癫痫药物的患者的富亮氨酸glioma-inactivated-1配体抗体(LGI1-Ab)自身免疫性癫痫(S11.003)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP S11.003 VO 90 15补充A1克里斯托弗羔羊A1杰弗里·布里顿A1肖恩Pittock A1 Avi Gadoth A1安德鲁·麦肯A1克里斯首页托弗·克莱因A1 Anteneh Feyissa年2018 UL //www.ez-admanager.com/content/90/15_Supplement/S11.003.abstract AB目的:描述发作符号学和实用的抗癫痫药物(AED)治疗富亮氨酸glioma-inactivated-1配体抗体(LGI1-Ab)自身免疫性癫痫(AE)。背景:AED疗法的作用LGI1-Ab AE是得不到重视,不清楚。设计/方法:我们确定了电压门控钾通道复杂患者(VGKCc)浓度高于0.02 nmol / L他们评估2008年5月- 2016年6月在梅奥诊所的三个地点(亚利桑那州、佛罗里达州、或明尼苏达州)。然后,我们回顾了只有患者LGI1 Ab +和癫痫发作。结果:我们发现1095例VGKCc浓度高于0.02 nmol / L, 77人LGI1-Ab积极。其中,56例癫痫患者进行了分析。表示平均年龄是62.9岁;66% (n = 37)是男性。最常见的癫痫符号学是面部与臂的矛盾的癫痫(增)(n = 35岁,63%)其次是焦点意识受损(FIA) (n = 29, 52%),广义tonic-clonic (gtc) (n = 28日50%),非机动车和焦点意识到(n = 28日50%)。有不止一个大多数癫痫发作类型(n = 49岁的88%;值= 2.5)。 38 patients (68%) became seizure free: 29 (76%) with immunotherapy, 5 (13%) with AEDs alone, and 4 (11%) with AEDs after immunotherapy. Levetiracetam (n=47, 84%) and Valproic acid (n=21, 38%) were the most commonly used AEDs, but neither conferred seizure freedom. AEDs with sodium channel blocking (NCB) properties rendered some seizure free, while non-NCB AEDs did not (9/50 vs 0/84, p=0.001). Patients with FBDS were more likely to respond to immunotherapy than to AEDs (20/30 vs 3/34, p=0.001). There was no difference in the rate of response between immunotherapy and AEDs in patients who presented with non-FBDS seizures. AED response was independent of MRI or EEG abnormalities, or presence of cognitive dysfunction.Conclusions: Although FBDS are the most characteristic seizure semiology seen in LGI1-Ab AE, others including FIA and GTCs also occur frequently. NCB AEDs were more likely to confer seizure freedom than other AEDs.Disclosure: Dr. Lamb has nothing to disclose. Dr. Britton has nothing to disclose. Dr. Pittock has nothing to disclose. Dr. Gadoth has nothing to disclose. Dr. McKeon has received research support from Medimmune, Euroimmun, Grifols and Alexion. Dr. Klein has nothing to disclose. Dr. Feyissa has nothing to disclose.