PT -期刊文章盟阿卜杜勒Kisekka Musubire AU -大卫Boulware盟Ana-Claire Meyer盟Akshaya拉梅什AU - Debarko纳杰盟大卫Meya AU -约瑟夫DeRisi AU -迈克尔·威尔逊TI -病因和结果在非创伤性脊髓损伤(P5.155)在乌干达DP - 2018年4月10 TA -神经病学PG - P5.155 VI - 90 IP - 15补充4099 - //www.ez-admanager.com/content/90/15_Supplement/P5.155.short 4100 - http://n.neurology.or首页g/content/90/15_Supplement/P5.155.full所以Neurology2018 4月10;90 AB -目的:确定病因和结果在人与非创伤性脊髓损伤(SCI)在乌干达。背景:创伤性脊髓病是一项具有挑战性的条件来管理,因为广泛的鉴别诊断和大量的地区差别。这种情况更为普遍比高收入国家在非洲。在撒哈拉以南非洲地区,非创伤性脊髓病相关的发病率和死亡率高,对病人和卫生系统重要的经济的影响。一些非洲研究到达最终诊断为硬膜内的或髓内非创伤性脊髓病的病因,因为诊断模式,如核磁共振和微生物学的测试,是罕见的。设计/方法:我们注册一个前瞻性群组的参与者在坎帕拉的姆拉戈医院与非创伤性脊髓病,乌干达在2013 - 2015。参与者进行临床评估,MRI (1.5 t)和CSF分析:基本的显微镜,文化,和宏基因组下一代测序(西班牙芒果)。参与者接受标准的护理管理和为期一年的随访。结果:与非创伤性科学,103名参与者(差)的年龄中值为37年(85年),和25%的人感染艾滋病毒。截瘫/下肢轻瘫是最常见的临床表现,70% (n = 72)。 Severe disease was present in 82% (n=85) as per the American Spinal Injury Association scale. On MRI, 50% had extradural lesions. However, bone lesions accounted for only 75% of all the extradural lesions (37% overall). Death occurred in 42% (n=44) of participants. Thirty participants had CSF analyzed, with 30% of the samples having pleocytosis with negative cultures for bacteria and fungi. mNGS of CSF identified: Kadipiro virus (n=13), HIV-1 (n=1), cytomegalovirus (n=1), and Epstein-Barr virus (n=2).Conclusions: The mortality following non-traumatic SCIs is high in Uganda. We demonstrated an equal distribution between extradural and intradural lesions. Mosquito-borne Kadapiro virus, only previously reported to cause fever in one person in Kenya, may be associated with non-traumatic SCI; however, this finding requires confirmatory testing.Study Supported by:Support for this research was received from the National Institute of Health and Fogarty International Center (R25TW009345, K24AI096925) and NIH_NOA 1k43TW010718Disclosure: Dr. Musubire has nothing to disclose. Dr. Boulware has nothing to disclose. Dr. Meyer has nothing to disclose. Dr. Ramesh has nothing to disclose. Dr. Banerji has nothing to disclose. Dr. Meya has nothing to disclose. Dr. DeRisi has nothing to disclose. Dr. Wilson has nothing to disclose.