TY -的T1 -在颞叶癫痫发作对认知功能的影响和成像特性(P2.265) JF -神经学乔-神经学六世- 90 - 15补充SP - P2.265盟Gyujoon黄盟耶底底亚马西斯AU -印度的七弦琴Nair盟盟梅根·罗兹曼-泰勒麦克首页米兰AU -考特尼Forseth盟鲦鱼Almane AU -布鲁斯·赫尔曼盟Neelima Tellapragada AU - Onyekachi Nwoke AU -科尔库克AU -安德鲁Nencka AU -拉姆Birn AU -伊丽莎白费尔顿AU -亚伦袭击非盟-罗摩Maganti AU -丽莎柯南特盟科林·汉弗莱斯Manoj Raghavan AU -埃德加DeYoe盟盟Vivek普拉巴卡兰AU -杰弗里粘合剂盟玛丽Meyerand Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/P2.265.abstract N2 -目的:本研究的主要目标是与颞叶癫痫的认知表现(框架)患者静息状态的功能连通性,并将这种关系与健康对照组进行比较。背景:框架是最常见的一种类型的癫痫反复发作是会影响认知功能的各个方面。然而,这些赤字的神经生物学的来源并不是充分的研究。框架设计/方法:49例(= 39.8±11.6岁、教育= 15.7±2.7年,女性25日),和31健康对照组(= 32.0±8.7岁、教育= 16.6±3.0年,女性14日)在癫痫的连接体项目(ECP)进行了分析。他们完成4 NIH工具箱认知测试:尺寸变化卡(行政/转移),侧卫抑制控制和注意力(行政/注意力),列表排序工作记忆、处理速度和模式比较。我们记录了age-corrected分数。他们也收到了20分钟的静息状态扫描使用小说同时摘要多层成像(8乐队,TR = 802毫秒,2.0毫米各向同性),和t1解剖扫描(0.8毫米各向同性)。预处理管道由人类连接体项目(HCP)的应用,和HCP格拉瑟的分割是用于连接矩阵。皮尔逊相关性认知特性和静止状态之间的连通性计算他们的关系。框架结果:患者表现明显比education-matched健康控制尺寸变化卡和处理速度。术;0.001)相关优势的左半球休息连接似乎是这些认知得分指数呈现负相关,而intra-hemispheric连接呈正相关。 The correlation strength between the right frontal eye fields and the left entorhinal cortex negatively impacted all 4 cognitive measures in TLE patients (p<0.004).Conclusions: We revealed resting state connections that correlated well with cognitive performances of TLE patients, which were found to be different compared to healthy controls. Characterizing neurobiological sources of the apparent cognitive deficits in TLE patients will facilitate the understanding of this elusive brain disorder.Study Supported by: NIH/NINDS grants U01 NS093650Disclosure: Dr. Hwang has nothing to disclose. Dr. Mathis has nothing to disclose. Dr. Nair has nothing to disclose. Dr. Rozman has nothing to disclose. Dr. McMillan has nothing to disclose. Dr. Forseth has nothing to disclose. Dr. Almane has nothing to disclose. Dr. Hermann has nothing to disclose. Dr. Tellapragada has nothing to disclose. Dr. Nwoke has nothing to disclose. Dr. Cook has nothing to disclose. Dr. Nencka has nothing to disclose. Dr. Birn has nothing to disclose. Dr. Felton has nothing to disclose. Dr. Struck has nothing to disclose. Dr. Maganti has nothing to disclose. Dr. Conant has nothing to disclose. Dr. Humphries has nothing to disclose. Dr. DeYoe has nothing to disclose. Dr. Raghavan has nothing to disclose. Dr. Prabhakaran has nothing to disclose. Dr. Binder has nothing to disclose. Dr. Meyerand has nothing to disclose. ER -