TY - T1的明确的脑淀粉样血管病相关肉芽肿炎症ApoE4的中年男子与等位基因纯合子。乔(P1.189) JF -首页神经-神经学六世- 90 - 15补充SP - P1.189盟燕侯AU -阿帕纳Vaddiparti盟Xianyuan歌AU -劳伦斯·哈德逊Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/P1.189.abstract N2 -目的:描述的脑淀粉样血管病相关炎症(CAA-I)与癫痫发作和多个皮质出血的中年男人。背景:最初的诊断标准提出了可能的CAA-RI涌和修改到可能或可能CAA-RI基于由格林伯格T2 hyperintensity模式的模式。明确诊断CAA-I取决于活检证实,伴随的血管炎症和淀粉样蛋白沉积。设计/方法:案例ReportResults: 52岁的前医生与抑郁症严重的广场恐怖症,安非他酮,最近诊断为见证了广义tonic-clonic发作后提出。历史是亚急性认知缺陷和严重的广场恐怖症引人注目他退出职业生涯。2头CT显示病灶(& lt;每1厘米)的右颞皮质出血和左顶叶。MRI显示大量皮质micro-hemorrhages上和infra-tentorial隔间CAA的暗示。他不满足原始或修改标准CAA-RI由于缺少T2天赋hyperintensities或leptomeningeal增强;但考虑到他的年龄相对年轻,担心恶性肿瘤被排除,对前颞叶活检进行。证实CAA-RI,肉芽肿性脉管炎透壁的炎症、纤维素样坏死,淀粉样蛋白沉积涉及leptomeningeal和皮质血管。 He had homozygous alleles for Apo-e4 on chromosome 19 that was previously described in association with CAA-I. He was treated with high-dose Methylprednisolone for 3 days and was placed on a Prednisone taper. He has remained seizure free on levetiracetam monotherapy at six months, with persisting cognitive deficits.Conclusions: In cases with high clinical suspicion, despite them not meeting the criteria for probable or possible CAA-I, a biopsy must be undertaken especially since steroids and other immune-modulatory agents have been shown to be beneficial in inflammatory exacerbations of CAA-I. This may be particularly true in patients with ApoE4 or other, as yet unknown genetic predispositions.Disclosure: Dr. Hou has nothing to disclose. Dr. Vaddiparti has nothing to disclose. Dr. Song has nothing to disclose. Dr. Hudson has nothing to disclose. ER -