@article {SmithP4.364作者={杰西卡·史密斯和紫水晶Leimpeter凯瑟琳·阿尔伯斯和埃里克Kerezsi Keeli McClearnen和斯蒂芬·范Eeden和安妮特Langer-Gould}, title ={维生素D和产后多发性硬化复发(P4.364)},体积={90}={15}补充数量,elocation-id = {P4.364} ={2018},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:确定低维生素D水平与产后复发的风险增加有关。首页背景:多发性硬化症(MS)影响有超过280000的美国女性,其中大多数在生育年龄发展疾病。产后复发的恐惧影响计划生育,治疗和选择母乳喂养,但很少有人知道如何降低复发风险。一个有吸引力的假说是维生素D-MS复发关系因为缺乏维生素D是流行在世界范围内,尤其是孕妇和哺乳期妇女,减少产后复发提供可能产生重大影响的策略。设计/方法:前瞻性跟踪调查了89名孕妇与Kaiser Permanente加州北部和南部的女士产后一年。血清浓度(25 ohd)使用液相色谱测定,串联质谱在怀孕后期,产后三个月。其他风险和结果收集从结构化访谈和电子健康记录。数据分析使用纵向多变量方法。结果:在怀孕期间,大多数女性(88 \ %)是足够的维生素D (\ > 30 ng / mL),产前维生素(93 \ %),但是没有额外补充维生素D (78 \ %)。中值25 ohd水平38 ng / mL(四分位范围,32 {\ textendash} 42)。降低妊娠水平并没有与产后复发的风险增加(\ < 40 ng / mL, p = 0.47)。在分娩后25 ohd水平下降(p \ <。)无论女性产后复发(28 \ %),或完全母乳喂养(48 \ %)。 Body mass index, race/ethnicity and season were all associated with 25OHD levels. However, after accounting for these factors, neither lower 25OHD levels during pregnancy nor the early postpartum period were associated with a higher risk of postpartum relapses.Conclusions: Lower vitamin D levels during pregnancy or early postpartum were not associated with an increased risk of postpartum relapses. Taken together with previous studies, our findings imply that extra vitamin D supplementation beyond prenatal vitamins is unlikely to decrease the risk of postpartum MS relapses.Study Supported by: National Multiple Sclerosis Society (RG4809-A PI: Langer-Gould)Disclosure: Dr. Smith has nothing to disclose. Dr. Leimpeter has nothing to disclose. Dr. Albers has nothing to disclose. Dr. Kerezsi has nothing to disclose. Dr. McClearnen has nothing to disclose. Dr. Van Den Eeden has nothing to disclose. Dr. Langer-Gould has nothing to disclose.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/90/15_Supplement/P4.364}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }