PT -期刊文章盟Chaoran马盟,奶油蛋白甜饼AU - Junjuan李盟刘英盟洁具太阳AU -哲黄盟要吴盟香高TI -饮酒和可能的REM睡眠行为障碍:一个以社区为基础的研究(P1.128) DP - 2018年4月10 TA -神经病学PG - P1.128 VI - 90 IP - 15补充4099 - //www.ez-admanager.com/content/90/15_Supplement/P1.128.short 4100 - //www.ez-admanager.com/content/90/15_Supplemen首页t/P1.128.full所以Neurology2018 4月10;90 AB -目的:系统地研究酒精摄入量之间的关系和风险的可能的REM睡眠行为障碍(pRBD)。背景:从最近的流行病学研究RBD的潜在风险因素,据报道与饮酒RBD或可能的RBD的风险更高。然而,迄今为止的大多数研究都相对较小或没有特别旨在评估使用的剂量和类型的酒精饮料。详细研究这种效应可以帮助了解酒精的潜在作用的发病机理不同的健康状况,RBD密切相关。设计/方法:研究包括了11905名参与者(平均年龄47.7岁):开滦的研究中,无中风、癌症、帕金森病、痴呆、和2006年头部受伤。我们决定使用验证pRBD RBD questionnaire-Hong香港在2012年。数量和类型的酒精摄入量与问卷调查收集。参与者被分为:不喝酒,光(女性:0 - 0.4份/ d;男人:0 - 0.9份/ d)、中度(女性:0.5 - -1.0次/ d; men: 1–2 servings/d), and heavy drinkers (women: >1 servings/d; men: >2 servings/d). To test differences in prevalence of pRBD across drinking status, we used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for demographic characteristics, smoking status, hypertension, diabetes, physical activity, body mass index, and plasma concentrations of lipids and urate.Results: Compared with non-current drinkers, current drinkers had a 23% higher risk of having pRBD (OR 1.23, 95% CI 1.07–1.59). Both moderate (adjusted OR: 1.53, 95% CI 1.01–2.30) and heavy drinkers (adjusted OR: 1.29, 95% CI 1.00–1.66) had a significantly higher risk of pRBD. There was a non-significant trend between consumption of each individual alcoholic beverages (i.e., beer, wine, or hard liquor) and higher risk of having pRBD (adjusted ORs ranged from 0.07 to 0.29).Conclusions: Alcohol consumption was associated with a higher risk of having pRBD.Study Supported by:This work was supported by the National Institute of Neurological Disorders And Stroke at the National Institutes of Health (NINDS 5R21NS087235-02 and 1R03NS093245-01A1).Disclosure: Dr. Ma has nothing to disclose. Dr. Pavlova has nothing to disclose. Dr. Li has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Sun has nothing to disclose. Dr. Huang has nothing to disclose. Dr. Wu has nothing to disclose. Dr. Gao has nothing to disclose.