% 0期刊文章%一个马库斯Ng % Eleni Giannouli % T肌肉在快速眼动睡眠的癫痫(P6.262) % D J神经病学2018% % P P6.262 % V 90% N 15补充% X目的:严格检查肌肉在快速眼动(REM)睡眠的癫痫首次使用一种新型定量脑电图仪的(QE首页EG)技术。背景:快速眼动睡眠通常抑制癫痫发作和癫痫痫性活动的人。在动物模型中,快速眼动睡眠没有弛缓已经被证明可以促进癫痫发作和癫痫样的活动。到目前为止,没有研究检查了快速眼动睡眠癫痫肌张力。设计/方法:QEEG软件分析连续记录在马尼托巴大学的癫痫脑电图监测单元(EMU)在12个月期间量化肌肉工件强度在REM睡眠。QEEG代表肌肉工件不同强度的绿色的酒吧。最大程度的绿色(M)计算作为一个RGB(红绿蓝)值来代表整个肌肉快速眼动睡眠的时代。帕金森症状患者被排除在外。结果:有790快速眼动睡眠时期从94例患者(平均年龄37.6岁,66%女性)。年龄和性别与m . 58例没有显著相关药物影响肌肉的能力。不是这些药物的患者,30癫痫(n = 272时代)和6 nonepileptic控制(n = 56时代)。 The mean age of epileptic and nonepileptic patients was 33 and 35 years respectively. While half of epileptic patients were male, all nonepileptic patients were female. M was significantly lower in epileptic patients (M=5.05 vs. 8.68, p<0.001). As additional controls, M was also calculated for patients outside the 12-month period: a nonepileptic patient with REM sleep behavior disorder (M=13.95), and another epileptic patient during a generalized tonic-clonic seizure (M=128).Conclusions: In this study, REM sleep muscle tone was significantly lower in epileptic patients than nonepileptic controls. Given the association of REM sleep without muscle atonia and seizure facilitation in animal models, this phenomenon may be a homeostatic protective mechanism against seizures in persons with epilepsy.Study Supported by:University of Manitoba Vice President Research Office, University Medical Group Department of Medicine GrantDisclosure: Dr. Ng has nothing to disclose. Dr. Giannouli has received research support from Respironics. %U

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