TY - T1的年龄复发对复苏的影响:一个EDSS-recovery模型神经病学临床试验(P2.375) JF -乔-神经学六世- 90 - 15补充SP - P2.375盟Burcu Zeydan AU - Britt首页ani康威盟伊丽莎白·j·阿特金森AU -卡门Castrillo-Viguera盟Orhun Kantarci Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/P2.375.abstract N2 -目的:我们研究了年龄对复发的影响复苏多发性硬化(MS)患者或临床孤立综合征(CIS)。背景:年龄可能影响复苏从高峰期间残疾达到疾病复发的独立修改药物使用。设计/方法:两个群体进行了研究:1)以人群为基础的奥姆斯特德县与复发缓和医学患者队列;2)安慰剂对照和治疗手臂从冠军和冠军与CIS患者试验。作为衡量病情复发的复苏,eds的变化计算通过与最大最小6个月时间实现复苏。以人群为基础的队列,配对分析每个病人的第一个和最后一个复发了。冠军组,第一个(CIS)复发了。在每个人口中位数eds变化是利用定义好的和可怜的回收器。结果:以人群为基础的队列,改进中值(Δ)峰值残疾在第一次复发1.5 eds (n = 161;平均年龄:30.5,Q1,第三:23.7,36.3;ΔEDSS< 1.5 = 45%,ΔEDSS≥1.5 = 55%)。这些病人,纵向130最后复发的详细信息与转向少复苏变老(平均年龄:44.0,Q1,第三:38.3,52.2; ΔEDSS<1.5=77%, ΔEDSS≥1.5=23%). In the clinical trial cohort, median improvement from the peak disability at 6 months was 0.0 EDSS (80% of patients had an EDSS score >0.0 at enrollment, n=234; median age: 33.5, Q1, Q3: 28.5,39.5; ΔEDSS<1=64%, ΔEDSS≥1=36%). As patients were stratified using the population-based cohort’s median age of 44, they also showed a shift towards less recovery with older age (age≤44.0; ΔEDSS<1=62%, ΔEDSS≥1=38%)(age>44.0; ΔEDSS<1=84%, ΔEDSS≥1=16%)(p=0.028).Conclusions: EDSS-based recovery model for relapses is sensitive to detect age-dependent changes in recovery in MS or CIS as tested both in a population-based setting and in a clinical trial setting. As patients get older, decreased amount of recovery is observed.Study Supported by: Biogen Inc.Disclosure: Dr. Zeydan has nothing to disclose. Dr. Conway has nothing to disclose. Dr. Atkinson has nothing to disclose. Dr. Castrillo-Viguera has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Employee of Biogen. Dr. Castrillo-Viguera holds stock and/or stock options in Holds stock/stock options in Biogen. Dr. Kantarci has nothing to disclose. ER -