TY - T1的血浆il - 6水平与功能结果和独立相关的标记在自发性脑出血继发损伤(P4.296) JF -神经学乔-神经学六世- 90 - 15补充SP - P4.296盟奥黛丽现有非盟-亚瑟Steinschneider盟圭多要求非盟-艾米丽·吉尔摩盟-劳伦无盟-凯文Sheth Y1 - 2018/04/10 UR - http://n.n首页eurology.org/content/90/15_Supplement/P4.296.abstract N2 -目的:这是推测,细胞因子水平可能与三个月的功能结果和有关放射标记的二次伤害。背景:脑出血后的炎症反应的影响(我)还没有被很好地表现为患者和对炎症的早期征兆之间的关系和功能的结果。设计/方法:54个患者自发我在安排转院前瞻性的医院。收集血液样本在24 (n = 44)和72年(n = 33)小时post-ICH。血浆细胞因子水平测量使用商用多路复用ELISA试剂盒(微孔)。改良Rankin规模(夫人)收集三个月通过电话面试。细胞因子之间的关联和使用序数物流回归结果进行了评估。线性回归是用来评估二次损伤的细胞因子水平和标记之间的联系。结果:il - 6与我相关(p = 0.003)和板式换热器体积体积单变量分析(p = 0.009)。在多变量分析中,il - 6与中线移位调整后我体积(p = 0.027)。24小时il - 6 (p & lt;0.001),il - 10 (p & lt;0.001),IL-15 (p = 0.001),格拉斯哥昏迷评分(GCS)承认,我卷,我得分,和外部心室排水(EVD)放置与更高(更糟糕的)在单变量序列回归的夫人。 After adjustment for the ICH score, 24h IL-6 (OR 2.00, 95% CI 1.2–3.3, p = 0.003) and IL-15 (OR 2.7, 95% CI 1.4–5.0, p = 0.007) were significantly associated with worse mRS.Conclusions: Plasma IL-6 is independently associated with 24h midline shift, a measure of global hemispheric swelling, and with functional outcome after spontaneous ICH. These data are consistent with the early robust increase in brain IL-6 in experimental models of ICH. These data warrant further investigation of IL-6 levels as a biomarker for secondary injury and poor outcome in ICH.Disclosure: Dr. Leasure has nothing to disclose. Dr. Steinschneider has nothing to disclose. Dr Falcone has nothing to disclose. Dr Gilmore has nothing to disclose. Dr. Sansing has nothing to disclose. Dr. Sheth has nothing to disclose. ER -