% 0期刊文章%一个贾斯汀穆南%布莱恩尼克% Guray Erus % Ilya纳斯鲁拉% Pam称%一个Lenore Launer Christos Davatzikos % % T白质显微结构的损伤和脑萎缩在中年。纵向贲门MRI亚组。(P3.178) % D J神经病学20首页18% % P P3.178 % V 90% N 15补充% X目的:探讨之间的关系最初的显微结构的完整性和总变化和大叶性脑组织在纵向贲门MRI∶中年混血儿的参与者。背景:扩散张量成像(DTI)是一种磁共振成像(MRI)技术,允许量化脑显微结构的完整性。越来越多的证据表明,改变大脑微观结构完整性先于老年人体积变化。现在还不知道如果DTI变化与脑容量在中年时的损失。设计/方法:参与者(n = 471;平均年龄50.4岁(SD - 3.5))进行了DTI和结构磁共振成像在两届点(平均随访时间4.7年(SD 0.4));分数各向异性(FA)和脑容量在cc量化。调整线性回归模型被用来研究基线之间的纵向关系FA和脑容量的变化。结果:高基线总白质FA与较小的白质总额下降在cc(β(95%置信区间):42.4 (0.73 - 84.0),P < 0.05),而不是总脑容量。Sub-analyses表明较高的基线水平的白质FA颞(β(95%置信区间):39.4−0.51到79.3,P = 0.05)和枕叶(β(95%置信区间):39.2 (0.39 - 78.0),P < 0.05),但不是在顶叶、额叶白质总额的下降减少了相关。 Associations were independent of age, sex, center, race and intra-cranial volume. FA in gray matter or in the total brain was not related to change in the respective tissue volumes.Conclusions: In middle-aged persons, initial lower white matter microstructural integrity was related to loss of white matter tissue over 5 years. White matter microstructural damage in midlife may be an indicator of risk for future white matter volume changes that are potentially clinically significant.Study Supported by: This study was supported by Contracts NOl-HC-48047, NOl-HC-48048. NOl-HC-48049 and NOl-HC-48050 from the National Heart, Lung, and Blood Institute, National Institutes of Health.Disclosure: Dr. Moonen has nothing to disclose. Dr. Bryan has nothing to disclose. Dr. Erus has nothing to disclose. Dr. Nasrallah has nothing to disclose. Dr. Schreiner has nothing to disclose. Dr. Davatzikos has nothing to disclose. Dr. Launer has nothing to disclose. %U