PT -期刊文章盟贾斯汀穆南AU -尼克·布莱恩盟Guray Erus AU - Ilya纳斯鲁拉盟Pam称非盟- Christos Davatzikos盟Lenore Launer TI -白质显微结构的损伤和脑萎缩在中年。纵向贲门MRI亚组。(P3.178) DP - 2018年4月10 TA -神经病首页学PG - P3.178 VI - 90 IP - 15补充4099 - //www.ez-admanager.com/content/90/15_Supplement/P3.178.short 4100 - //www.ez-admanager.com/content/90/15_Supplement/P3.178.full所以Neurology2018 4月10;90 AB -目的:调查初始微观结构完整性和变化之间的关系和大叶性脑组织总纵贲门MRI∶在中年混血儿的参与者。背景:扩散张量成像(DTI)是一种磁共振成像(MRI)技术,允许量化脑显微结构的完整性。越来越多的证据表明,改变大脑微观结构完整性先于老年人体积变化。现在还不知道如果DTI变化与脑容量在中年时的损失。设计/方法:参与者(n = 471;平均年龄50.4岁(SD - 3.5))进行了DTI和结构磁共振成像在两届点(平均随访时间4.7年(SD 0.4));分数各向异性(FA)和脑容量在cc量化。调整线性回归模型被用来研究基线之间的纵向关系FA和脑容量的变化。结果:高基线总白质FA与小白质总额下降cc(β(95%置信区间):42.4 (0.73 - 84.0),P & lt; 0.05),但不是总脑容量。 Sub-analyses suggested that higher baseline levels of white matter FA in the temporal (Beta [95% CI]: 39.4 [−0.51 to 79.3], P=0.05) and occipital lobes (Beta [95% CI]: 39.2 (0.39 to 78.0), P<0.05), but not in the parietal or frontal lobes, were related to less decline in total white matter volume. Associations were independent of age, sex, center, race and intra-cranial volume. FA in gray matter or in the total brain was not related to change in the respective tissue volumes.Conclusions: In middle-aged persons, initial lower white matter microstructural integrity was related to loss of white matter tissue over 5 years. White matter microstructural damage in midlife may be an indicator of risk for future white matter volume changes that are potentially clinically significant.Study Supported by: This study was supported by Contracts NOl-HC-48047, NOl-HC-48048. NOl-HC-48049 and NOl-HC-48050 from the National Heart, Lung, and Blood Institute, National Institutes of Health.Disclosure: Dr. Moonen has nothing to disclose. Dr. Bryan has nothing to disclose. Dr. Erus has nothing to disclose. Dr. Nasrallah has nothing to disclose. Dr. Schreiner has nothing to disclose. Dr. Davatzikos has nothing to disclose. Dr. Launer has nothing to disclose.