PT -期刊文章盟罗伯特·威尔逊AU -基督教Crouzet AU -穆罕默德Torabzadeh盟Afsheen Bazrafkan AU - Dishant Donga盟盟Shuhab·胡安Alcocer AU -伯纳德•崔盟-布鲁斯Tromberg盟阎罗王阿克巴里TI -一个多通道光学成像平台,预测神经复苏后心脏骤停在一个“动物Neuro-Intensive病房”(S42.003) DP - 2018年4月10 TA -神经病学PG - S42.003 VI - 90 IP - 15补充4099 - //www.ez-admanager.com/content/90/15_Supplement/S42.003.short 4100 - //www.ez-admanager.com/content/90/15_Supplement/S42.003.full所以Neurolo首页gy2018 4月10;90 AB -目的:开发一种多通道平台,模拟一个neuro-intensive病房(ICU)提高定量了解脑血流(CBF)之间的关系,新陈代谢,电活动后心脏骤停(CA)和心肺复苏术(CPR)在临床前模型。背景:超过550000人每年遭受CA。病人通常进入昏迷,努力恢复神经认知功能,很少实现完整的神经恢复。除了针对36°C核心温度,目前没有成熟的技术来治疗CA患者已经明确证明改善长期的结果。设计/方法:获得clinically-translational洞察大脑反应CA和心肺复苏,我们开发了一个老鼠进入CA的临床前模型,接收心肺复苏,并逐渐引起昏迷,在连续多通道监测:动脉血压、脑电图(EEG),激光散斑成像(LSI)和多光谱空间频率域成像(SFDI)。大规模集成电路提供了关于CBF的信息,和多光谱SFDI措施脑氧合和组织散射。时间的动态与脑电图LSI和SFDI数据进行比较,以确定CBF之间的关系,代谢和脑电活动。结果:恢复脑电图在时间分辨CBF CPR恰逢拐点之后,氧化,脑氧代谢率。这些拐点对应CBF脱钩的动脉血压。Time-integrated CBF是脑电图恢复的预测。最大的初始时期脑电图复苏之际,从CBF-driven过渡到氧气extraction-driven血液动力学。Conclusions: Our preclinical model and multimodal monitoring setup can provide previously-unseen insights into cerebral response to ischemia (CA) and reperfusion (CPR). Our system obtains quantitative metrics describing the relationship between CBF, metabolism, and EEG. These metrics are obtained directly on the brain, providing new methods for predicting EEG recovery and identifying specific modifiable parameters (e.g., blood flow and oxygenation) during crucial time windows where modifying these quantities may improve outcome.Study Supported by: NIH Trailblazer R21 grant (1R21EB024793-01)NIH NCATS (UCI ICTS) KL2 grant via UL1 TR000153NIH CTSA (UCI ICTS) TL-1 Postdoctoral Training Award (1TL1TR001415-01)NIH/NIBIB Funded Laser Microbeam and Medical Program (LAMMP) (P41EB015890)Disclosure: Dr. Wilson has nothing to disclose. Dr. Crouzet has nothing to disclose. Dr. Torabzadeh has nothing to disclose. Dr. Bazrafkan has nothing to disclose. Dr. Donga has nothing to disclose. Dr. Zaher has nothing to disclose. Dr. Alcocer has nothing to disclose. Dr. Choi has nothing to disclose. Dr. Tromberg has nothing to disclose. Dr. Akbari has nothing to disclose.