TY - T1的变化在大脑功能和结构的连接体沿着阿尔茨海默病连续(P3.033) JF -神经学乔-神经学六世- 90 - 15补充SP - P3.033盟Federica Agosta AU -西尔维亚Basaia盟- Elisa Canu盟弗首页朗西斯卡imperiale AU -朱塞佩·马格纳尼盟莫妮卡Falautano AU -吉安卡洛Comi AU -安德里亚Falini盟-马西莫菲利皮主持Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/P3.033.abstract N2 -目的:探讨结构和脑功能网络体系结构在阿尔茨海默病(AD)患者和遗忘轻度认知障碍(aMCI),分层在转换器(c-aMCI)和non-converters (nc-aMCI)广告;并评估健康的大脑网络功能连通性之间的关系和脑萎缩的地形沿着广告连续的病人。背景:研究疾病对大脑的影响网络广告连续是概念化的关键和预测网络疾病体内进化。设计/方法:公元九十四年患者、47 aMCI病人(25 c-aMCI在36个月),53岁,sex-matched健康进行了3 d t1加权磁共振扩散张量磁共振成像和静息状态功能磁共振成像。图分析和评估——全球和本地拓扑网络结构和功能属性和区域连接。健康的大脑区域的拓扑特性评估基于连接的点最大萎缩(中心)在广告和aMCI病人。结果:大脑网络图分析AD患者严重改变属性。大脑结构网络已经改变c-aMCI患者相对于健康对照组尤其是颞叶和顶叶的脑区,而功能连通性并没有改变。结构连接改变杰出c-aMCI nc-aMCI病例。在广告和c-aMCI,最大的意义是位于左海马萎缩(disease-epicenter)。大脑区域最强烈与disease-epicenter健康功能连接体也最萎缩性广告和c-aMCI病人。Conclusions: Progressive degeneration in the AD continuum is associated with an early breakdown of anatomical brain connections and follows the strongest connections with the disease-epicenter. These findings support the hypothesis that the topography of brain connectional architecture can modulate the spread of AD through the brain.Study Supported by: The study was supported by the Italian Ministry of Health (grant number GR-2010-2303035) and Alzheimer’s Drug Discovery Foundation (grant number 20131211).Disclosure: Dr. Agosta has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with EXCEMED— Excellence in Medical Education. Dr. Basaia has nothing to disclose. Dr. Canu has nothing to disclose. Dr. imperiale has nothing to disclose. Dr. Magnani has nothing to disclose. Dr. Falautano has nothing to disclose. Dr. Comi has nothing to disclose. Dr. Falini has nothing to disclose. Dr. Filippi has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biogen Idec, Merk-Serono, Novartis, Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in an editorial capacity for Journal of Neurology. Dr. Filippi has received research support from Biogen Idec, Novartis, Teva Pharmaceutical Industries. ER -