PT -期刊文章盟阴暗Rahayel盟-罗纳德·b·Postuma AU -雅克Montplaisir盟盟偏头痛•高柏达芙妮Genier玛珊德盟- Frederique Escudier盟Pierre-Alexandre Bourgouin AU -朱莉载体盟Oury Monchi AU -斯文Joubert盟让Gagnon TI -皮层下基础的认知障碍特发性快速眼动睡眠行为障碍(S17.005) DP - 2018年4月10 TA -神经病学PG - S17.005 VI - 90 IP - 15补充4099 - //www.ez-admanager.com/content/90/15_Supplement/S17.005.short 4100 - //www.ez-admanager.com/content/90/15_Supplement/S17.005.full所以Neurology2018 4首页月10;90 AB -目的:旨在探讨皮层下形状异常的底层iRBD患者的认知缺陷。背景:特发性快速眼动睡眠行为障碍(iRBD)是帕金森病的主要危险因素,与路易体痴呆。此外,从33%到50%的iRBD患者表现为轻度认知障碍(MCI)。设计/方法:t1影像是在52名患者使用3 t MRI polysomnography-confirmed iRBD,包括17 MCI患者和健康对照组。所有参与者进行一个完整的神经心理学评估考试和神经。基于顶点的形状分析调查表面皮层下结构的异常在三组之间。我们也进行了相关性分析iRBD患者之间的皮层下形状和认知能力(复合z分数在三个认知域,即关注和执行功能,学习和记忆,和视觉空间的能力)。结果:存在MCI iRBD病人与左壳核、丘脑皮层下形状收缩。控制相比,iRBD MCI患者还显示异常形状收缩核,螺旋体和丘脑。没有区别iRBD病人没有MCI和控制。 Lower performance in attention and executive functions was associated with shape in the striatum, lower performance in learning and memory with shape in the hippocampus, amygdala, and thalamus, and lower performance in visuospatial abilities with shape in the hippocampus.Conclusions: Cognitive deficits in iRBD patients are associated with gray matter subcortical contraction. These abnormalities correlate with cognitive performance of iRBD patients. Our results highlight the importance of distinguishing between subgroups of iRBD patients on the basis of their cognitive profile in order to develop a better comprehension of neurodegeneration in this population.Study Supported by: This work was supported by the Canadian Institutes of Health Research, Fonds de Recherche du Québec – Santé, and W. Garfield Weston Foundation.Disclosure: Dr. Rahayel has nothing to disclose. Dr. Postuma has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Biotie, Roche/Prothena, Teva Neurosciences, Jazz Pharmaceuticals, Novartis Canada, Theranexus, GE HealthCare, . Dr. Montplaisir has nothing to disclose. Dr. Gaubert has nothing to disclose. Dr. Genier-Marchand has nothing to disclose. Dr. Escudier has nothing to disclose. Dr. Bourgouin has nothing to disclose. Dr. Carrier has nothing to disclose. Dr. Monchi has nothing to disclose. Dr. Joubert has nothing to disclose. Dr. Gagnon has nothing to disclose.