TY - T1的谜军事脑损伤:初步分析扩散磁共振成像措施(S49.006) JF -神经学乔-神经学六世- 90 - 15补充SP - S49.006盟-艾米丽丹尼斯盟伊丽莎白·王尔德AU -兰德尔Scheibel盟玛雅Troy首页anskaya AU -卡门·维盟-本杰明·韦德盟安玛丽Drennon AU -杰拉尔德纽约盟艾琳Bigler AU -特雷西Abildskov AU -布莱恩·泰勒盟-卡洛斯Jaramillo盟Blessen Eapen AU -希瑟Belanger盟-玛丽Newsome AU -哈维·莱文AU -西德尼·希德AU -威廉·沃克AU -保罗汤普森AU -大卫·泰特Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/S49.006.abstract N2 -目的:确定可再生的差异扩散磁共振成像(dMRI)措施军事脑损伤,使用多个军团的荟萃分析。背景:创伤性脑损伤(TBI)是最常见的一种损伤影响的美国军队和武装成员服务全球。受伤会影响战备具有抑制受损阶段,延伸在不久的,也会导致长期认知障碍和不良健康后果。扩散磁共振成像(dMRI)提供了脑损伤的敏感指标,并补充更传统的成像模式。只有少数研究dMRI用于军事脑损伤和他们发现混合的结果,一定程度上是由于有限的权力在小样本。设计/方法:受试者评估从4个不同的项目总共369创伤性脑损伤/脑震荡参与者和202比较参与者不诊断为创伤性脑损伤。包含的所有组参与者美国退伍军人或现役军人。所有网站处理dMRI脑部扫描本地标准协议(http://enigma.usc.edu)。FA(分数各向异性)平均在63的roi JHU(约翰霍普金斯大学)阿特拉斯。计算了创伤性脑损伤/控制效应的大小在每个队列中,并将所有的军团的统计结果进行荟萃分析个人的回归参数。结果:我们发现在创伤性脑损伤明显高于FA上纵束(SLF p = 0.0011)。外部胶囊(EC)和后丘脑的辐射(PTR)显示边缘效应。Conclusions: Some studies have shown higher FA in concussed individuals even months post-injury, when edema, which could lead to increased FA calculations initially, has already resolved. Animal studies have indicated that higher FA after mild injury could be a marker of fiber reorganization and remyelination. Identifying imaging biomarkers of brain injury in the military will help us better understand injury and recovery processes, and ultimately may assist in the assessment of more effective treatments.Study Supported by: ELD is supported by a grant from the NINDS (K99 NS096116). ELD and PT are also supported by NIH grants to PT: U54 EB020403, R01 AG040060, and R01 NS080655. DoD ADNI is supported by the NCIRE (DoD W81XWH-12-2-0012). The Chronic Effects of Neurotrauma Consortium is supported by grants PT108802-SC104835 and W81XWH-13-2-0095 from the Department of Defense and grant 5I01RX002174 from the VA. A Longitudinal Study of Chronic TBI in OEF/OIF/OND Veterans and Service Members is supported by grant funding from the VA (study number O1062-I; grant number: 5I01RX001062). Funding for the iSCORE study was provided by the Defense and Veterans Brain Injury Centers, U.S. Army Medical Research and Materiel Command (USAMRMC; W81XWH-13-2-0025). This material is based in part upon work supported by the U.S. Army Medical Research and Material Command and from the U.S. Department of Veterans Affairs. The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. Any opinions, findings, conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the U.S. Government, the U.S. Department of Veterans Affairs, or the U.S. Department of Defense, and no official endorsement should be inferred.Disclosure: Dr. Dennis has nothing to disclose. Dr. Wilde has nothing to disclose. Dr. Scheibel has nothing to disclose. Dr. Troyanskaya has nothing to disclose. Dr. Velez has nothing to disclose. Dr. Wade has nothing to disclose. Dr. Drennon has nothing to disclose. Dr. York has nothing to disclose. Dr. Bigler has nothing to disclose. Dr. Abildskov has nothing to disclose. Dr. Taylor has nothing to disclose. Dr. Jaramillo has nothing to disclose. Dr. Eapen has nothing to disclose. Dr. Belanger has nothing to disclose. Dr. Newsome has nothing to disclose. Dr. Levin has nothing to disclose. Dr. Hinds has nothing to disclose. Dr. Walker has nothing to disclose. Dr. Thompson has nothing to disclose. Dr. Tate has nothing to disclose. ER -