TY - T1的发散Bi-hemispheric FTLD-TDP模式和FTLD-Tau神经病理学在原发性进行性失语(P1.185) JF -神经学乔-神经学六世- 90 - 15补充SP - P1.185 AU -卢西亚Giannini盟-曼迪梁AU -科里麦克米兰盟安首页德鲁威廉姆斯AU -查尔斯·杰斯特盟Katya Rascovsky AU -大卫Wolk盟沙龙灰非盟-爱德华·李盟约翰Trojanowski AU -莫里格罗斯曼盟大卫欧文Y1 - 2018/04/10 UR - //www.ez-admanager.com/content/90/15_Supplement/P1.185.abstract N2 -目的:探讨神经病理学的区域分布在整个半球原发性进行性失语(PPA)和潜在的额颞叶大叶性变性(FTLD),并与事后病理学TDP-43患者经临床特征(FTLD-TDP)和τ(FTLD-Tau)神经病理学。背景:PPA是由FTLD-Tau或FTLD-TDP proteinopathies在大多数病人,但left-lateralized病理已经很少了,量化的病理学一直使用传统的顺序测量不精确,而这些疾病已经很少,经临床特征相关。设计/方法:回顾性研究的尸检群FTLD-PPA (n = 27),我们使用一部小说,量化在脑组织病理学验证,数字图像的方法。我们分析事后一侧,白质(WM)灰色物质(GM)病理负担,和地区分布的病理学FTLD-TDP FTLD-Tau。我们相关的病理学负担,经临床特征和定量核磁共振大脑皮层厚度(CT)。结果:病理剩下两FTLD-Tau单侧性的(p = 0.003)和FTLD-TDP (p = 0.011)。FTLD-Tau had higher relative WM burden than FTLD-TDP (p<0.001). In left-hemisphere GM, FTLD-Tau had highest pathology in mid-frontal cortex (MFC) and FTLD-TDP in orbitofrontal cortex (OFC). In direct between-group comparisons, FTLD-Tau had greater pathology in left MFC than FTLD-TDP (p=0.029), while FTLD-TDP had more in left OFC than FTLD-Tau (p<0.001). Across the total cohort, left MFC pathology burden was associated with nonfluent speech (p=0.017) and left OFC burden with single-word comprehension impairment (p=0.045). Post-mortem density of pathology in GM was negatively associated with ante-mortem MRI CT (p=0.007), and, similar to digital pathology results, FTLD-Tau had lowest CT in MFC while FTLD-TDP had lowest CT in OFC.Conclusions: Microscopic pathology in PPA is lateralized to the left hemisphere with divergent anatomic distributions in FTLD-Tau and FTLD-TDP, and these are related to ante-mortem clinical features and MRI structural imaging.Study Supported by: NS044266, AG038490, AG015116, AG010124, P01NS053488, P01AG032953, P01AG017586, AG043503, NS088341, Penn Institute on Aging, Wyncote Foundation.Disclosure: Dr. Giannini has nothing to disclose. Dr. Liang has nothing to disclose. Dr. McMillan has nothing to disclose. Dr. Williams has nothing to disclose. Dr. Jester has nothing to disclose. Dr. Rascovsky has nothing to disclose. Dr. Wolk has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Merck, Jannsen, Eli Lilly, and GE. Dr. Ash has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Trojanowski has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Johnson & Johnson. Dr. Grossman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with GE Whitney. Dr. Grossman has received personal compensation in an editorial capacity for Neurology. Dr Irwin has nothing to disclose. ER -