@article {MariottoP1.389作者={莎拉Mariotto利维亚而和塞尔吉奥·法拉利和另·卡普拉奇亚拉Mancinelli和阿德里亚娜Bonora和罗伯特·Bombardi萨尔瓦多摩纳哥和阿尔贝托Gajofatto马库斯Reindl}, title ={比较白细胞介素6的水平在中枢神经系统炎症条件下根据Aquaporin-4和髓少突细胞糖蛋白抗体状态(P1.389)},体积={90}={15}补充数量,elocation-id = {P1.389} ={2018},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:比较患者白介素6(白细胞介素6)水平在不同的中枢神经系统炎症性疾病包括视neuromyelitis谱系障碍(NMOSD) anti-aquaporin 4抗体阳性(AQP4-Ab) anti-myelin少突细胞糖蛋白抗体(MOG-Ab)相关条件,特发性视神经炎(上)、特发性脊髓炎(AM)和多发性硬化症(MS)。首页背景:增加脑脊液(CSF)患者白细胞介素6的水平一直在观察NMOSD,女士相比,和可能的预测因素疾病严重程度和治疗目标在严重的情况下。然而,有争议的结果已报告在血清中白细胞介素6的水平在这些条件和血清和CSF值之间的相关性。设计/方法:我们分析了患者血清白细胞介素6水平21 AQP4-ab NMOSD有关,与复发缓和女士25例,8科目进步女士,13,患者15例,23日主题MOG-Ab相关条件和15名健康对照组使用ELISA。我们还测试了6脑脊液样本包括MOG-Ab阳性患者和10例配对血清和脑脊液样本女士发病。结果:血清白细胞介素6中观察到没有统计显著差异水平在不同的包括组(p = 0.08)。然而,显著增加的脑脊液白细胞介素6的值是指出MOG-Ab阳性病例(中位数77.5 pg / ml,范围2.4 {\ textendash} 215.56)相比,女士(平均0.001,0.001 {\ textendash} 3.8)。结论:像AQP4-ab阳性病例脑脊液白细胞介素6的水平可能是一个有用的生物标志物MOG-Ab积极主题。现在需要进一步的研究来阐明是否anti-IL6受体抗体治疗也可能是一个潜在的治疗选择在这些条件。披露:Mariotto博士没有披露。博士而没有披露。法拉利博士已经收到个人赔偿咨询、担任科学顾问委员会说,或其他活动与夏尔在意大利参加神经学会议。博士·卡普拉已收到个人赔偿咨询,担任科学顾问委员会说,或其他活动与诺华,生原体,Teva, Genzyme和Sanofi-Aventi演讲费。Mancinelli博士没有披露。 Dr. Bonora has nothing to disclose. Dr. Bombardi has nothing to disclose. Dr. Monaco has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Honoraria from Biogen. Dr. Gajofatto has received research support from Research support funding from Merck. Dr. Reindl has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Speaker honoraria and compensation of travel costs from Chugai. Dr. Reindl has received research support from The Neurological Research Laboratory (Markus Reindl, Medical University of Innsbruck and Tirol Kliniken) receives payments for antibody assays (AQP4- and anti-neuronal antibodies) and for AQP4- and MOG-antibody validation experiments organized by Euroimmu.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/90/15_Supplement/P1.389}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }