PT -期刊文章盟-阿卡什Virupakshaiah盟-马里诺Dalakas盟Neeja德赛AU -斯科特·明茨盟杰弗里•拉TI -报告LGI1脑炎与肺鳞状细胞癌(p2.2 - 028) DP - 2019年4月09年TA -神经病学第六PG - p2.2 - 028 - 92 IP - 15补充4099 - //www.ez-admanager.com/content/92/15_supplement/p2.2 028. - 028.短4100 - http://n.neurology.o首页rg/content/92/15_supplement/p2.2 - -全所以Neurology2019 4月09年;92 AB -目的:N /背景:N / aIntroduction:自身免疫性脑炎有不同表现,通常表现为边缘或脑干脑炎。LGI1脑炎礼物与亚急性认知障碍、心理障碍、运动障碍,面部与臂的矛盾的发作。LGI1脑炎病例的设置局部肺鳞状细胞癌。案例:一个78岁的女人与乳腺癌的历史地位后切除和辐射,没有之前神经历史被评估。她典型的面部与臂的矛盾的癫痫发作,影响左比右手臂和面部肌张力障碍和声音有关。他们每天发生大约二十次。她有认知功能障碍、构音障碍、发音过弱。她的神经系统检查显示左侧轻微动作迟缓。脑电图的情节并没有发现癫痫活动。 Given the semiology of the episodes, LGI1 encephalitis was strongly suspected. Initial paraneoplastic panel was positive for VGKC antibodies without LGI1 positive serologies. The patient was started on IVIG and Solumedrol for empiric treatment of immune-mediated encephalitis. Repeated titers for the LGI1 antibody complex were positive. She had partial improvement of her seizures despite IVIG, Levetiracetam, and Clonazepam. Seven months following her presentation, she was found to have a lung mass. Surgical resection demonstrated Stage I Small Cell Carcinoma. Following the resection, she had complete resolution of seizure activity and cognitive function. She was able to come off IVIG and anti-convulsants.Discussion: LGI1 encephalitis is typically not associated with malignancy. There has been no reported case of association between squamous cell carcinoma of the lung and LGI1 encephalitis. This case suggests that surveillance for systemic malignancy should be more considered in cases of LGI1 autoimmunity.Results: n/aConclusions: n/aDisclosure: Dr. Virupakshaiah has nothing to disclose. Dr. Dalakas has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Mintzer has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Eisai, UCB, Abbvie,Greenwich Laboratories. Dr. Mintzer has received research support from UCB. Dr. Ratliff has nothing to disclose.