TY - T1的皮质atrophyin一级无症状non-familial-TLE病人的亲属(S3.007) JF -神经学乔-神经学六世- 92 - 15补充SP - S3.007盟Marilise Katsurayama A首页U - Jose Carlos Moreira盟维多利亚Ferraz AU -塔米尔Zanao Nogueira盟盟——Mateus -滨Alvim盟Leticia里贝罗盟Iscia Lopes-Cendes盟——费尔南多Cendes盟——克拉丽莎Yasuda Y1 - 2019/04/09 UR - //www.ez-admanager.com/content/92/15_Supplement/S3.007.abstract N2 -目的:我们旨在研究遗传因素通过分析大脑皮层和皮层下一级的测量结果无症状的亲属non-familial颞叶癫痫患者(框架)。背景:双边结构大脑改变通常框架中确定,,不一定与癫痫发作有关。新,研究调查了遗传框架结构改变的一个重要因素。有寻找生物标记,证明了家族的作用框架;因此,定量核磁共振研究已经被用来评估皮质改变他们的无症状的亲戚。设计/方法:我们邀请了58框架的直系亲属无症状,零星的患者(无神经系统疾病和从未发作)。亲戚相比,六十九名健康志愿者(成对的年龄(p = 0.13)和性(p = 0.9)。高分辨率3 d-t1加权图像(1 mm3的各向同性体素)都根据标准划分SPM12 /猫12 (http://www.neuro.uni-jena.de/cat/)协议包括:空间标准化(mni - 152),组织分割、平滑和图像分割的质量控制。皮层下卷(海马、杏仁核、尾状核、苍白球、丘脑和壳核)提取Freesurfer 5.3 (https://surfer.nmr.mgh.harvard.edu/)。统计比较与SPM / CAT12皮质地图进行,而临床和皮层下的数据进行了分析和多变量分析SPSS 23。结果:没有观察到皮层下结构的差异群体之间的任何6个结构评估在两个半球(F (5106) = 0.56;p = 0.74; partial eta-squared (η2)=0.03]. However, we identified a significant reduction of cortical thickness on asymptomatic relatives compared to healthy controls in the left postcentral gyrus, bilateral parietal superior gyrus and precuneus (p<0.05, corrected with FDR).Conclusions: Areas of atrophy identified in first-degree relatives of TLE patients strongly suggest a heritable condition/trait. Further studies of brain connectivity with functional MRI and white matter with Diffusion Tensor Images may reveal subtle alterations to corroborate this hypothesis and further understanding the extension of heritability of brain abnormalities in TLE.Disclosure: Dr. Katsurayama has nothing to disclose. Dr. Moreira has nothing to disclose. Dr. Ferraz has nothing to disclose. Dr. Zanão has nothing to disclose. Dr. Nogueira has nothing to disclose. Dr. Alvim has nothing to disclose. Dr. Ribeiro has nothing to disclose. Dr. Lopes-Cendes has nothing to disclose. Dr. Cendes has nothing to disclose. Dr. Yasuda has nothing to disclose. ER -