PT -期刊文章盟詹姆斯Siegler AU -史蒂文展览馆AU -海蒂Sucharew盟Tapan Mehta AU - Niraj Arora AU -艾米Starosciak AU -费利佩•德洛里奥斯La Rosa AU -娜塔莎威尔盟Akshitkumar Mistry AU -联合国开发Patel盟萨尔曼·阿萨德AU -阿姆土耳其帽盟凯蒂Dakay AU -杰夫·瓦格纳盟艾丽西娅·班尼特盟Bharathi Jagadeesan AU -克里斯托弗Streib盟-斯图尔特韦伯盟-罗翰Chitale AU -约翰沃尔皮盟-斯蒂芬Mayer盟Shadi Yaghi AU - Mahesh Jayaraman盟Pooja Khatri盟——伊娃Mistry TI -低估的缺血性核心灌注CT在急性患者大血管闭塞:最好的前瞻性队列研究的结果(p5.3 - 050) DP - 2019年4月09年TA -神经病学第六PG - p5.3 - 050 - 92 IP - 15补充4099 - //www.ez-admanager.com/content/92/15_supplement/p5.3 050. - 050.短4100 - //www.ez-admanager.com/content/92/15_supplement/p5.3 - -全所以Neurology2019 4月09年;首页92 AB -目的:确定之间的相关程度,unenhanced CT及CT灌注核心大血管闭塞患者的梗死体积。背景:2018年美国医院协会指南建议急性大血管闭塞患者的血栓切除术(LVO)被认为是基于灌注成像6到24小时的窗口。在6小时内,CT灌注(CTP)核心估计可能低估了不可逆转的梗死体积可视化unenhanced CT;然而这并没有在以后的时间窗口。设计/方法:采用多中心前瞻性群组的病人血栓切除术为LVO 0-24最后正常后几小时,我们相关的基线CTP核心梗塞体积(rCBF< 30%)和unenhanced CT方面得分。我们比较CTP发现患者之间一个不利的方面(& lt; 6)对那些有有利的方面(≥6),随着时间的推移和评估结果。结果:443例,165人接受了CTP包括(平均年龄69 y, 50%女性,平均8 (IQR 6 - 9)和9 cc(差0-28))的核心。方面和核心卷适度相关(r =−0.35,术中;0.01)。一个没有核心(0 cc)是观察到32%的患者,其中方面得分中值为8 (IQR 8 - 10)。 After adjustment for age and baseline NIHSS, the ASPECTS score declined significantly over time (cOR 1.05, 95%CI 1.01–1.10, p=0.01), while the core (p=0.69) and penumbra volumes (p=0.74) remained unchanged.Conclusions: In this multi-center prospective cohort of patients who underwent thrombectomy, one-third of patients had normal core infarct volumes despite half of these patients showing irreversible infarction on the unenhanced CT (ASPECTS ≤8). As time progresses, the unenhanced CT demonstrates evolution of irreversible infarction, whereas the perfusion core appears static. This finding emphasizes the need to carefully assess both unenhanced CT and CTP when considering thrombectomy eligibility in the late time window.Disclosure: Dr. Siegler has nothing to disclose. Dr. Messe has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Claret Medical, Inc. Dr. Messe has received research support from WL Gore & Associates, Bayer, and Mallinkrodt. Dr. Sucharew has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Arora has nothing to disclose. Dr. Starosciak has nothing to disclose. Dr. De Los Rios La Rosa has nothing to disclose. Dr. Barnhill has nothing to disclose. Dr. Mistry has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Assad has nothing to disclose. Dr. Tarboosh has nothing to disclose. Dr. Dakay has nothing to disclose. Dr. Wagner has nothing to disclose. Dr. Bennett has nothing to disclose. Dr. Jagadeesan has nothing to disclose. Dr. Streib has nothing to disclose. Dr. Weber has nothing to disclose. Dr. Chitale has nothing to disclose. Dr. Volpi has nothing to disclose. Dr. Mayer has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Idorsia, Edge, and NFL. Dr. Yaghi has nothing to disclose. Dr. Jayaraman has nothing to disclose. Dr. Khatri has nothing to disclose. Dr. Amin has nothing to disclose.